J
Joleen Kajdas
Researcher at Johns Hopkins University
Publications - 3
Citations - 1693
Joleen Kajdas is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Virus & Viremia. The author has an hindex of 3, co-authored 3 publications receiving 1526 citations. Previous affiliations of Joleen Kajdas include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.
Janet D. Siliciano,Joleen Kajdas,Diana Finzi,Thomas C. Quinn,Thomas C. Quinn,Karen Chadwick,Joseph B. Margolick,Colin Kovacs,Stephen J. Gange,Robert F. Siliciano +9 more
TL;DR: It is shown that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly that eradication is unlikely.
Journal ArticleDOI
Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads.
Deborah Persaud,George K. Siberry,Aima Ahonkhai,Joleen Kajdas,Daphne Monie,Nancy Hutton,Douglas C. Watson,Thomas C. Quinn,Thomas C. Quinn,Stuart C. Ray,Robert F. Siliciano,Robert F. Siliciano +11 more
TL;DR: It is demonstrated that viremia persists in children with plasma virus levels below the limit of detection of clinical assays, and in most children on HAART with clinically undetectable vire Mia, there is continued virus production without evolution of resistance in the protease gene.
Journal ArticleDOI
Slow Human Immunodeficiency Virus Type 1 Evolution in Viral Reservoirs in Infants Treated with Effective Antiretroviral Therapy
Deborah Persaud,Stuart C. Ray,Joleen Kajdas,Aima Ahonkhai,George K. Siberry,Kimberly Ferguson,Carrie Ziemniak,Thomas C. Quinn,Joseph P. Casazza,Steven L. Zeichner,Stephen J. Gange,Douglas C. Watson +11 more
TL;DR: HAART initiated from early infancy does not prevent the establishment of a reservoir of latent provirus, but does significantly limit the evolution of HIV-1 in viral reservoirs, which may have implications for long-term pharmacologic control ofAIDS.