J
Joseph B. Margolick
Researcher at Johns Hopkins University
Publications - 396
Citations - 39728
Joseph B. Margolick is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Multicenter AIDS Cohort Study & Acquired immunodeficiency syndrome (AIDS). The author has an hindex of 89, co-authored 385 publications receiving 36654 citations. Previous affiliations of Joseph B. Margolick include Ohio State University & University of Pittsburgh.
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Journal ArticleDOI
Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy
Diana Finzi,Monika Hermankova,Theodore C. Pierson,Lucy M. Carruth,Christopher B. Buck,Richard E. Chaisson,Thomas C. Quinn,Karen Chadwick,Joseph B. Margolick,Ron Brookmeyer,Joel E. Gallant,Martin Markowitz,David D. Ho,Douglas D. Richman,Robert F. Siliciano +14 more
TL;DR: In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes, and generally did not show mutations associated with resistance to the relevant antiretroviral drugs.
Journal ArticleDOI
Plasma Viral Load and CD4+ Lymphocytes as Prognostic Markers of HIV-1 Infection
John W. Mellors,Alvaro Muñoz,Janis V. Giorgi,Joseph B. Margolick,Charles J. Tassoni,Phalguni Gupta,Lawrence A. Kingsley,John Todd,Alfred J. Saah,Roger Detels,John P. Phair,Charles R. Rinaldo +11 more
TL;DR: This study compared the prognostic value of plasma viral load with that of clinical, serologic, and cellular markers in a large cohort of HIV-infected men and incorporated the two most predictive markers-plasma viral load and CD4+ lymphocyte count-into a regression tree that is useful for assessing the prognosis of individual patients.
Journal ArticleDOI
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Tae Wook Chun,Lucy M. Carruth,Diana Finzi,Xuefei Shen,Joseph A. DiGiuseppe,Harry E. Taylor,Monika Hermankova,Karen Chadwick,Joseph B. Margolick,Thomas C. Quinn,Thomas C. Quinn,Yen Hong Kuo,Ron Brookmeyer,Martha A. Zeiger,Patricia Barditch-Crovo,Robert F. Siliciano +15 more
TL;DR: It is shown that during the asymptomatic phase of infection there is an extremely low total body load of latently infected resting CD4+ T cells with replication-competent integrated pro virus (<107 cells).
Journal ArticleDOI
Latent infection of CD4 + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Diana Finzi,Joel N. Blankson,Janet M. Siliciano,Joseph B. Margolick,Karen Chadwick,Theodore C. Pierson,Kendall A. Smith,Julianna Lisziewicz,Franco Lori,Charles Flexner,Thomas C. Quinn,Richard E. Chaisson,Eric S. Rosenberg,Bruce D. Walker,Stephen J. Gange,Joel E. Gallant,Robert F. Siliciano +16 more
TL;DR: The mean half-life of the latent reservoir was very long (43.9 months) and the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable as mentioned in this paper.
Journal ArticleDOI
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.
Janet D. Siliciano,Joleen Kajdas,Diana Finzi,Thomas C. Quinn,Thomas C. Quinn,Karen Chadwick,Joseph B. Margolick,Colin Kovacs,Stephen J. Gange,Robert F. Siliciano +9 more
TL;DR: It is shown that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly that eradication is unlikely.