Jolein Gloerich

TL;DR: Evidence for a fourth pathway to produce oxygen is presented, possibly of considerable geochemical and evolutionary importance, and opens up the possibility that oxygen was available to microbial metabolism before the evolution of oxygenic photosynthesis.

TL;DR: It is shown that N2H4 is produced from the anammox substrates ammonium and nitrite and that nitric oxide is the direct precursor of N2 H4, which presents a new biochemical reaction forging an N–N bond and fills a lacuna in understanding of the biochemical synthesis of the N2 in the atmosphere.

TL;DR: Adaptations of Scalindua to the substrate limitation of the ocean may include highly expressed ammonium, nitrite and oligopeptide transport systems and pathways for the transport, oxidation, and assimilation of small organic compounds that may allow a more versatile lifestyle contributing to the competitive fitness of ScalIndua in the marine realm.

TL;DR: The results demonstrate that two closely related metabolic enzymes have diverged at the root of the vertebrate lineage to function in two separate mitochondrial metabolic pathways and have clinical implications for the diagnosis of complex I deficiency.

TL;DR: An iterative orthology prediction method that uses reciprocal best hits at the level of sequence profiles to infer orthology, which increases ortholog detection by 20% compared to sequence-to-sequence comparisons and takes advantage of divergent orthology relations among homologous proteins.