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Edwin Lasonder
Researcher at University of Plymouth
Publications - 68
Citations - 5039
Edwin Lasonder is an academic researcher from University of Plymouth. The author has contributed to research in topics: Plasmodium falciparum & Proteome. The author has an hindex of 32, co-authored 68 publications receiving 4640 citations. Previous affiliations of Edwin Lasonder include Leiden University & Northumbria University.
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Journal ArticleDOI
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry
Edwin Lasonder,Edwin Lasonder,Yasushi Ishihama,Jens S. Andersen,Adriaan M. W. Vermunt,Arnab Pain,Robert Sauerwein,Wijnand Eling,Neil Hall,Andrew P. Waters,Hendrik G. Stunnenberg,Matthias Mann +11 more
TL;DR: A large-scale, high-accuracy mass spectrometric proteome analysis of selected stages of the human malaria parasite Plasmodium falciparum revealed 1,289 proteins that contain domains that indicate a role in cell–cell interactions, and therefore can be evaluated as potential components of a malaria vaccine formulation.
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Proteome Analysis of Separated Male and Female Gametocytes Reveals Novel Sex-Specific Plasmodium Biology
Shahid M. Khan,Blandine Franke-Fayard,Gunnar R. Mair,Edwin Lasonder,Edwin Lasonder,Chris J. Janse,Matthias Mann,Andrew P. Waters +7 more
TL;DR: The male gametocyte has the most distinct proteome, containing many proteins involved in flagellar-based motility and rapid genome replication, and new sex-specific regulatory pathways were defined.
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MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
Xavier Le Guezennec,Michiel Vermeulen,Arie B. Brinkman,Wieteke A. M. Hoeijmakers,Adrian Cohen,Edwin Lasonder,Hendrik G. Stunnenberg +6 more
TL;DR: Ch Chromatin immunoprecipitation experiments revealed that PRMT5 and MBD2 are recruited to CpG islands in a methylation-dependent manner in vivo and that H4R3, a substrate of PRMT, is methylated at these loci.
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Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.
Gunnar R. Mair,Edwin Lasonder,Lindsey S. Garver,Lindsey S. Garver,Blandine Franke-Fayard,Celine Carret,Joop Wiegant,Roeland W. Dirks,George Dimopoulos,Chris J. Janse,Andrew P. Waters,Andrew P. Waters +11 more
TL;DR: Plasmodium P granules is defined as an ancient mRNP whose protein core has remained evolutionarily conserved from single-cell organisms to germ cells of multi-cellular animals and stores translationally silent mRNAs that are critical for early post-fertilization development during the initial stages of mosquito infection.
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Protein Export Marks the Early Phase of Gametocytogenesis of the Human Malaria Parasite Plasmodium falciparum
Francesco Silvestrini,Edwin Lasonder,Anna Olivieri,Grazia Camarda,Ben C. L. van Schaijk,Massimo Sanchez,Sumera Younis Younis,Robert W. Sauerwein,Pietro Alano +8 more
TL;DR: This work indicates that protein export profoundly marks early sexual differentiation in P. falciparum, probably contributing to host cell remodeling in this phase of the life cycle, and that gametocyte-enriched molecules are recruited to modulate this process in gametocytogenesis.