Jon E. Peterson

TL;DR: Platelets sequester angiogenesis regulatory proteins which suggests an avenue for developing biomarkers to monitor disease and Multivariable logistic regression analysis indicated that PDGF, PF4 and VEGF were independent predictors of colorectal carcinoma and as a set provided statistically significant discrimination.

TL;DR: Evidence is presented that changes in platelet-associated platelet factor-4 (PF-4) detect malignant growth across a spectrum of human cancers in mice and concludes that platelets-associated PF-4, but not its plasma counterpart, may represent a potential biomarker of early tumor presence.

TL;DR: The LAL test is not a valid measure of all parameters of toxicity of a lipid A or lipid A-like compound and can yield false-positive results, but these findings are not in conflict with the widespread use of the LAL assay for pyrogens in the pharmaceutical industry.

TL;DR: Comparison of chromatographic fractions reveals that components of toxic and nontoxic lipid A can be paired according to structure, andStructural analogs of monophosphoryl lipid A, which differ in degree of O-acylation and type and distribution of fatty acids, have comparable antitumor activity.

TL;DR: Results indicate that HCV core antigen can be identified by routine serological ELISA in specimens from the early antibody–negative phase of HCV infection.