Jon Espen Dale

TL;DR: There were considerable variations between the estimations of RBE and RBE-weighted doses from the different models and these variations were a consequence of fundamental differences in experimental databases, model assumptions and regression techniques.

TL;DR: No case of local recurrence could be explained by inadequate mMKM target coverage that was not already present in the LEM plan and new constraints have been defined for optic pathways and brainstem to improve target coverage with no expected increase in tissue complications.

TL;DR: PT reduced the volumes of normal tissues exposed to radiation, particularly low-to-intermediate dose levels, and this was reflected in lower NTCP.

TL;DR: The current practice of particle reirradiation at CNAO for recurrent neoplasms in the H&N region results in acceptable rates of CB, and there were no CB cases in the carbon ion group even though this was the large majority of patients.

TL;DR: This work aims to update the local effect model (LEM)-based constraints for the rectum using microdosimetric kinetic model (mMKM)-defined values, relying on RBE translation and the analysis of long-term clinical outcomes.