J
Jonathan G. Frye
Researcher at United States Department of Agriculture
Publications - 141
Citations - 7135
Jonathan G. Frye is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 38, co-authored 131 publications receiving 5845 citations. Previous affiliations of Jonathan G. Frye include University of Washington & University of Georgia.
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Journal ArticleDOI
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database
Baofeng Jia,Amogelang R. Raphenya,Brian Alcock,Nicholas Waglechner,Peiyao Guo,Kara K. Tsang,Briony A. Lago,Biren M. Dave,Sheldon K. Pereira,Arjun N. Sharma,Sachin Doshi,Mélanie Courtot,Raymond Lo,Laura E. Williams,Jonathan G. Frye,Tariq Elsayegh,Daim Sardar,Erin L. Westman,Andrew C. Pawlowski,Timothy A. Johnson,Fiona S. L. Brinkman,Gerard D. Wright,Andrew G. McArthur +22 more
TL;DR: The Comprehensive Antibiotic Resistance Database (CARD) is a manually curated resource containing high quality reference data on the molecular basis of antimicrobial resistance (AMR), with an emphasis on the genes, proteins and mutations involved in AMR.
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Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides
Martin Bader,William Wiley Navarre,Whitney Shiau,Hiroshi Nikaido,Jonathan G. Frye,Michael McClelland,Ferric C. Fang,Samuel I. Miller +7 more
TL;DR: This study shows that exposure of S. typhimurium to sublethal concentrations of CAMP activates the PhoP/PhoQ and RpoS virulence regulons, while repressing the transcription of genes required for flagella synthesis and the invasion‐associated type III secretion system.
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Gene expression patterns during swarming in Salmonella typhimurium: genes specific to surface growth and putative new motility and pathogenicity genes
TL;DR: It is reported here the identification of putative new genes involved in motility and virulence, as judged by differential regulation of nearly one‐third of the functional genome in bacteria growing on the surface of agar.
Journal ArticleDOI
Co‐regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ
William Wiley Navarre,Thomas A. Halsey,Don Walthers,Jonathan G. Frye,Michael McClelland,Jennifer L. Potter,Linda J. Kenney,John S. Gunn,Ferric C. Fang,Stephen J. Libby,Stephen J. Libby +10 more
TL;DR: The absence of almost all SlyA‐activated genes from the Escherichia coli K12 genome suggests that the functional linkage between the SlyA and PhoP/PhoQ regulatory systems arose as Salmonella evolved its distinctive pathogenic lifestyle.
Journal ArticleDOI
Global regulation by CsrA in Salmonella typhimurium.
Sara D. Lawhon,Jonathan G. Frye,M. Mitsu Suyemoto,Steffen Porwollik,Michael McClelland,Craig Altier +5 more
TL;DR: Results show that csrA controls a number of gene classes in addition to those required for invasion, some of them unique to Salmonella, and suggests a co‐ordinated bacterial response to conditions that exist at the site of bacterial invasion, the intestinal tract of a host animal.