J
Jonathan Ma
Researcher at Virginia Commonwealth University
Publications - 11
Citations - 318
Jonathan Ma is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Neutrophil elastase & Cystic fibrosis. The author has an hindex of 4, co-authored 8 publications receiving 171 citations. Previous affiliations of Jonathan Ma include Boston Children's Hospital.
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Journal ArticleDOI
Mucins, Mucus, and Goblet Cells
TL;DR: Insight into the innate immune properties of mucins and goblet cells support a shift from the current paradigm of repressing increased mucin expression to targeting regulation of specific mucins or mucin hyperconcentration in the abnormal airway milieu.
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Cystic Fibrosis Sputum Rheology Correlates With Both Acute and Longitudinal Changes in Lung Function.
TL;DR: There are dramatic increases in dynamic viscosity and elasticity during a pulmonary exacerbation with return to baseline at recovery, which suggests that sputum viscoelastic properties are tightly associated with lung function and disease status.
Journal ArticleDOI
Neutrophil Extracellular Traps Increase Airway Mucus Viscoelasticity and Slow Mucus Particle Transit.
Rosalie S Linssen,Guihong Chai,Jonathan Ma,Apparao B. Kummarapurugu,Job B. M. van Woensel,Reinout A. Bem,Logan Kaler,Gregg A. Duncan,Lei Zhou,Bruce K. Rubin,Qingguo Xu +10 more
TL;DR: It is hypothesized that the extracellular DNA and/or oxidative stress e.g. by the release of reactive oxygen species (ROS) and myeloperoxidase (MPO) during NETs formation in the airways would increase mucus viscoelasticity.
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Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery.
Guihong Chai,Amr Hassan,Tuo Meng,Lihua Lou,Jonathan Ma,Russell Simmers,Lei Zhou,Bruce K. Rubin,Qi Tony Zhou,P. Worth Longest,Michael Hindle,Qingguo Xu +11 more
TL;DR: The MIP released from the EEG aerosol had human airway mucus and CF sputum diffusion properties comparable to the suspension formulation, which makes this formulation a promising pulmonary drug delivery system for CF lung infections.
Journal ArticleDOI
Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps: Relevance to CF.
Apparao B. Kummarapurugu,Shuo Zheng,Jonathan Ma,Shobha Ghosh,Adam M. Hawkridge,Judith A. Voynow +5 more
TL;DR: In this paper, neutrophil extracellular traps increase cystic fibrosis (CF) airway inflammation by clipping of chromatin binding proteins and the release of METs, a mechanism to augment NE-induced airway inflammatory in CF.