J
Jonathan P. Godbout
Researcher at Ohio State University
Publications - 64
Citations - 5853
Jonathan P. Godbout is an academic researcher from Ohio State University. The author has contributed to research in topics: Neuroinflammation & Microglia. The author has an hindex of 36, co-authored 64 publications receiving 4533 citations. Previous affiliations of Jonathan P. Godbout include The Ohio State University Wexner Medical Center.
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Review: Microglia of the aged brain: primed to be activated and resistant to regulation
TL;DR: The purpose of this review is to discuss the current understanding of age‐associated microglial priming, consequences of priming and reactivity, and the impairments in regulatory systems that may underlie these age‐related deficits.
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Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines
TL;DR: Findings provide novel evidence that age-associated priming of microglia plays a central role in exaggerated neuroinflammation induced by activation of the peripheral innate immune system.
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Microglia Priming with Aging and Stress
TL;DR: The characteristics of neuroinflammatory signaling and microglial sensitization in aging, its implications in psychological stress, and interventions that reverse aging-associated deficits are delved into.
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Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety.
Daniel B. McKim,Daniel B. McKim,Michael D. Weber,Michael D. Weber,Anzela Niraula,Anzela Niraula,Caroline M. Sawicki,Xiaoyu Liu,Brant L. Jarrett,Brant L. Jarrett,Karol Ramirez-Chan,Yufen Wang,Rachel M. Roeth,Ana D. Sucaldito,Carly G. Sobol,Ning Quan,John F. Sheridan,Jonathan P. Godbout,Jonathan P. Godbout +18 more
TL;DR: It is hypothesized that chronic stress drives the production of inflammatory monocytes that are actively recruited to the brain by microglia, and these monocytes augment neuroinflammatory signaling and prolong anxiety.
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TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation.
TL;DR: In this article, the effect of interleukin (IL)-10 on the activation of microglia under inflammatory conditions was investigated, and it was shown that IL-10 increased the production of transforming growth factor (TGF)-β and attenuated microglial activation.