J
Jonathan P. Sleeman
Researcher at Heidelberg University
Publications - 190
Citations - 15411
Jonathan P. Sleeman is an academic researcher from Heidelberg University. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 55, co-authored 180 publications receiving 14241 citations. Previous affiliations of Jonathan P. Sleeman include University of Freiburg & Karlsruhe Institute of Technology.
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Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
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CD44 is required for two consecutive steps in HGF/c-Met signaling
TL;DR: Signal transduction from activated c-Met to MEK and Erk required the presence of the cytoplasmic tail of CD44 including a binding motif for ERM proteins, which suggests a role forERM proteins and possibly their link to the cortical actin cytoskeleton in signal transfer.
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Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.
TL;DR: It is clear that cells can also bind and respond to HA directly, via cell-surface HA-binding proteins, suggesting that other ligands for these receptors may be involved.
Journal Article
CD44 Variants but not CD44s Cooperate with β1-containing Integrins to Permit Cells to Bind to Osteopontin Independently of Arginine-glycine-aspartic Acid, thereby Stimulating Cell Motility and Chemotaxis
Yohko U. Katagiri,Jonathan P. Sleeman,Hideki Fujii,Peter Herrlich,Hiroshi Hotta,Kumiko Tanaka,Shunsuke Chikuma,Hideo Yagita,Ko Okumura,Masaaki Murakami,Ikuo Saiki,Ann F. Chambers,Toshimitsu Uede +12 more
TL;DR: The expression of osteopontin, CD44 variants, and integrins has been correlated with tumorigenesis and metastasis and it is shown that these proteins cooperate to enhance cell motility.