J
Jonathan R. McDaniel
Researcher at University of Texas at Austin
Publications - 47
Citations - 3418
Jonathan R. McDaniel is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Antibody & Drug delivery. The author has an hindex of 26, co-authored 45 publications receiving 2811 citations. Previous affiliations of Jonathan R. McDaniel include Research Triangle Park & Pfizer.
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Journal ArticleDOI
Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection.
J. Andrew MacKay,Mingnan Chen,Jonathan R. McDaniel,Wenge Liu,Andrew J. Simnick,Ashutosh Chilkoti +5 more
TL;DR: Artificial recombinant chimeric polypeptides (CPs) that spontaneously self-assemble into sub-100 nm size, near monodisperse nanoparticles upon conjugation of diverse hydrophobic molecules, including chemotherapeutics are developed.
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Recursive Directional Ligation by Plasmid Reconstruction Allows Rapid and Seamless Cloning of Oligomeric Genes
TL;DR: A new strategy, recursive directional ligation by plasmid reconstruction (PRe-RDL), to rapidly clone highly repetitive polypeptides of any sequence and specified length over a large range of molecular weights.
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Drug delivery to solid tumors by elastin-like polypeptides.
TL;DR: This article reviews four applications of ELPs to drug delivery, with each delivery mechanism designed to best exploit the relationship between the characteristic transition temperature (t) of the ELP and body temperature (T(b).
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Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.
TL;DR: These studies suggest that electrospray is an efficient and flexible method for generating stimuli-responsive drug particles, and indicate that particle diameter, polydispersity, and morphology are strong functions of the solvent concentration, spraying voltage, and polymer molecular weight.
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A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models
Jayanta Bhattacharyya,Joseph J. Bellucci,Isaac Weitzhandler,Jonathan R. McDaniel,Ivan Spasojevic,Xinghai Li,Chao-Chieh Lin,Jen-Tsan Ashley Chi,Ashutosh Chilkoti +8 more
TL;DR: The authors conjugate paclitaxel to recombinant chimeric polypeptides that self-assemble into therapeutic nanoparticles that outperform Abraxane in murine tumour models.