Jonathan S. T. Woodhead

TL;DR: The uniqueness of the exosomal miRNA response suggests its relevance as a sample pool that needs to be further explored in better understanding biological functions.

TL;DR: In this paper, the authors showed that mitochondrial-encoded MOTS-c can significantly enhance physical performance in young (2 mo), middle-age (12 mo), and old (22 mo) mice.

TL;DR: The evidence that endogenous MDPs are sensitive to changes in metabolism is reviewed, showing that metabolic conditions like obesity, diabetes and aging are associated with lower circulating MSPs and treatment of rodents with humanin, MOTS-c and SHLP2 can enhance insulin sensitivity and offer protection against a range of age-associated metabolic disorders.

TL;DR: MOTS-c is an exercise-induced mitochondrial-encoded peptide that significantly enhanced physical performance when administered to young, middle- aged, and old mice, indicating that aging is regulated by genes that are encoded not only in the nuclear genome, but also in the mitochondrial genome.

TL;DR: It is shown that in healthy young men, peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function and do not adapt in response to a training intervention that increases Muscle mitochondrial function, suggesting PBMCs are a poor marker of muscle mitochondrialfunction in humans.