J
Jong Hyun Cho
Researcher at Emory University
Publications - 20
Citations - 1288
Jong Hyun Cho is an academic researcher from Emory University. The author has contributed to research in topics: Phosphoramidate & Nucleoside. The author has an hindex of 10, co-authored 18 publications receiving 1148 citations.
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Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.
TL;DR: The classic Huisgen 1,3-dipolar cycloaddition reaction between acetylenes and azides was brought back into focus by Sharpless and others when they developed the concept of click chemistry as mentioned in this paper.
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Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs
Jadd R. Shelton,Xiao Lu,Joseph A. Hollenbaugh,Jong Hyun Cho,Franck Amblard,Raymond F. Schinazi +5 more
TL;DR: This review focuses on the chemical synthesis and biology of anticancer nucleoside, nucleotide, and base analogs that are FDA-approved and in clinical development since 2000 and explores analog syntheses as well as improved and scale-up syntheses.
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Chutes and ladders in hepatitis C nucleoside drug development
Steven J. Coats,Ethel C. Garnier-Amblard,Franck Amblard,Maryam Ehteshami,Sheida Amiralaei,Hongwang Zhang,Longhu Zhou,Sebastien Boucle,Xiao Lu,Lavanya Bondada,Jadd R. Shelton,Hao Li,Peng Liu,Chengwei Li,Jong Hyun Cho,Satish N. Chavre,Shaoman Zhou,Judy S. Mathew,Raymond F. Schinazi +18 more
TL;DR: Nucleoside analogs that target the HCV NS5B polymerase that have reached human clinical trials is the focus of this review as they have demonstrated significant advantages in the clinic with broader activity against the various HCV GT and a higher barrier to the development of resistant viruses when compared to all other classes of HCV inhibitors.
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Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection.
TL;DR: An efficient method for the synthesis of nucleoside phosphoramidates prodrugs (6a-f) has been developed that employs a simple protection/deprotection sequence of the nucleosides with benzyloxycarbonyl (Cbz).