J
Jong Hyun Cho
Researcher at Emory University
Publications - 20
Citations - 1288
Jong Hyun Cho is an academic researcher from Emory University. The author has contributed to research in topics: Phosphoramidate & Nucleoside. The author has an hindex of 10, co-authored 18 publications receiving 1148 citations.
Papers
More filters
Journal ArticleDOI
Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
Seema Mengshetti,Longhu Zhou,Ozkan Sari,Coralie De Schutter,Hongwang Zhang,Jong Hyun Cho,Sijia Tao,Leda Bassit,Kiran Verma,Robert A. Domaoal,Maryam Ehteshami,Yong Jiang,Reuben Ovadia,Mahesh Kasthuri,Olivia Ollinger Russell,Tamara R. McBrayer,Tony Whitaker,Judy Pattassery,Maria Luz G. Pascual,Lothar Uher,Biing Y. Lin,Sam Lee,Franck Amblard,Steven J. Coats,Raymond F. Schinazi +24 more
TL;DR: A preliminary oral pharmacokinetics study in male beagles showed that 28 is superior to 27 and is an attractive candidate for further studies to establish its potential value as a new clinical anti-HCV agent.
Journal ArticleDOI
Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094
Maryam Ehteshami,Sijia Tao,Tugba Ozturk,Longhu Zhou,Jong Hyun Cho,Hongwang Zhang,Sheida Amiralaei,Jadd R. Shelton,Xiao Lu,Ahmed Khalil,Robert A. Domaoal,Richard A. Stanton,Justin E. Suesserman,Biing Lin,Sam S. Lee,Franck Amblard,Tony Whitaker,Steven J. Coats,Raymond F. Schinazi +18 more
TL;DR: DAPN-PD1 is characterized as a novel and potent antiviral agent that combines the delivery of two active metabolites that are inhibitors of NS5B-mediated RNA polymerization in vitro and in vivo.
Journal ArticleDOI
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase
Maryam Ehteshami,Longhu Zhou,Sheida Amiralaei,Jadd R. Shelton,Jong Hyun Cho,Hongwang Zhang,Hao Li,Xiao Lu,Tugba Ozturk,Richard A. Stanton,Franck Amblard,Tamara R. McBrayer,Steven J. Coats,Raymond F. Schinazi +13 more
TL;DR: The in vitro nucleotide substrate specificity of POLRMT was studied in order to explore structure-activity relationships that can facilitate the identification of nontoxic NAIs, and these findings have important implications for the development of all anti-RNA virus NAIs.
Journal ArticleDOI
Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.
TL;DR: Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide 15f exhibited modest selective anti-HIV-1 activity (EC50 = 24 µM).
Journal ArticleDOI
Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.
TL;DR: An efficient synthetic route to biologically relevant (-)-5-fluorocarbodine 6 was developed, allowing for a facial selective hydrogenation of the sugar double bond to give the desired 4'-β stereoisomer.