J
Jongsoon Lee
Researcher at Harvard University
Publications - 47
Citations - 17783
Jongsoon Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin resistance & Insulin receptor. The author has an hindex of 30, co-authored 43 publications receiving 16394 citations. Previous affiliations of Jongsoon Lee include Brigham and Women's Hospital & Soonchunhyang University.
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Journal ArticleDOI
Inflammation and insulin resistance
TL;DR: The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.
Journal ArticleDOI
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Dongsheng Cai,Minsheng Yuan,Daniel Frantz,Daniel Frantz,Peter A. Melendez,Peter A. Melendez,Lone Hansen,Jongsoon Lee,Steven E. Shoelson +8 more
TL;DR: It is shown that lipid accumulation in the liver leads to subacute hepatic 'inflammation' through NF-κB activation and downstream cytokine production, which causes insulin resistance both locally in liver and systemically.
Journal ArticleDOI
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Minsheng Yuan,Nicky Konstantopoulos,Jongsoon Lee,Lone Hansen,Zhi-Wei Li,Michael Karin,Steven E. Shoelson +6 more
TL;DR: It is shown that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling and identifies the IKKβ pathway as a target for insulin sensitization.
Journal ArticleDOI
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Markus Feuerer,Laura Herrero,Laura Herrero,Daniela Cipolletta,Afia Naaz,Jamie Wong,Jamie Wong,Ali Nayer,Jongsoon Lee,Allison B. Goldfine,Christophe Benoist,Steven E. Shoelson,Diane Mathis +12 more
TL;DR: Observations suggest that harnessing the anti-inflammatory properties of Treg cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
Journal ArticleDOI
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Dongsheng Cai,J. Daniel Frantz,J. Daniel Frantz,Nicholas E. Tawa,Nicholas E. Tawa,Peter A. Melendez,Peter A. Melendez,Byung-Chul Oh,Byung-Chul Oh,Hart G.W. Lidov,Hart G.W. Lidov,Per-Olof Hasselgren,Per-Olof Hasselgren,Walter R. Frontera,Walter R. Frontera,Jongsoon Lee,Jongsoon Lee,David J. Glass,Steven E. Shoelson,Steven E. Shoelson +19 more
TL;DR: This article showed that activation of NF-kappaB, through muscle-specific transgenic expression of activated IkappaB kinase beta (MIKK), causes profound muscle wasting that resembles clinical cachexia.