J
Joon-Ho Sheen
Researcher at Massachusetts Institute of Technology
Publications - 2
Citations - 719
Joon-Ho Sheen is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: mTORC2 & Cancer. The author has an hindex of 2, co-authored 2 publications receiving 678 citations.
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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
David A. Guertin,Deanna Stevens,Maki Saitoh,Stephanie Kinkel,Katherine Crosby,Joon-Ho Sheen,David J. Mullholland,Mark A. Magnuson,Hong Wu,David M. Sabatini +9 more
TL;DR: It is shown that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice, and that deleting one copy of Rictor protects Pten heterozygous mice from prostate cancer.
Journal ArticleDOI
mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
David A. Guertin,Deanna Stevens,Maki Saitoh,Stephanie Kinkel,Katherine Crosby,Joon-Ho Sheen,David J. Mullholland,Mark A. Magnuson,Hong Wu,David M. Sabatini +9 more
TL;DR: In this article, it was shown that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice and that Rictor is a haploinsufficient gene and that deleting one copy protected Pten heterozygous mice from prostate cancer.