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Stephanie Kinkel
Researcher at Massachusetts Institute of Technology
Publications - 4
Citations - 848
Stephanie Kinkel is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: mTORC2 & Cancer. The author has an hindex of 4, co-authored 4 publications receiving 799 citations.
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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
David A. Guertin,Deanna Stevens,Maki Saitoh,Stephanie Kinkel,Katherine Crosby,Joon-Ho Sheen,David J. Mullholland,Mark A. Magnuson,Hong Wu,David M. Sabatini +9 more
TL;DR: It is shown that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice, and that deleting one copy of Rictor protects Pten heterozygous mice from prostate cancer.
Journal ArticleDOI
mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
David A. Guertin,Deanna Stevens,Maki Saitoh,Stephanie Kinkel,Katherine Crosby,Joon-Ho Sheen,David J. Mullholland,Mark A. Magnuson,Hong Wu,David M. Sabatini +9 more
TL;DR: In this article, it was shown that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice and that Rictor is a haploinsufficient gene and that deleting one copy protected Pten heterozygous mice from prostate cancer.
Journal ArticleDOI
Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity.
TL;DR: A dynamic, temperature-dependent requirement for XBP-1 and PEK-1 activities that increases with immune activation and at elevated physiological temperatures in C. elegans is defined, suggesting that the negative feedback loops involving the activation of IRE-1-XBP- 1 and PEk-1 pathways serve essential roles, not only at the extremes of ER stress, but also in the maintenance of ER homeostasis under physiological conditions.
Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity
TL;DR: In this paper, the authors show that in Caenorhabditis elegans XBP-1 deficiency results in constitutive endoplasmic reticulum (ER) stress, reflected by increased basal levels of IRE-1 and PEK-1 activity under physiological conditions.