J
Jordan Todd
Researcher at University of California, San Diego
Publications - 2
Citations - 154
Jordan Todd is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Innate immune system & Neutrophil extracellular traps. The author has an hindex of 2, co-authored 2 publications receiving 112 citations.
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Journal ArticleDOI
IL-1β is an innate immune sensor of microbial proteolysis
Christopher N. LaRock,Jordan Todd,Doris L. LaRock,Joshua Olson,Anthony J. O’Donoghue,Avril A. B. Robertson,Mark E. Cooper,Hal M. Hoffman,Victor Nizet,Victor Nizet +9 more
TL;DR: It is found that GAS protease SpeB directly activates IL-1β independent of host inflammasome proteins and this may account for more frequent GAS infections in rheumatoid arthritis patients receiving anakinra, which may represent an ancestral system of innate immune regulation.
Journal ArticleDOI
Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing
Christopher N. LaRock,Simon Döhrmann,Jordan Todd,Ross Corriden,Joshua Olson,Timo Johannssen,Bernd Lepenies,Richard L. Gallo,Partho Ghosh,Victor Nizet,Victor Nizet +10 more
TL;DR: Exogenous M1 protein rescues M1-deficient GAS from killing by neutrophils and within neutrophil extracellular traps and neutralizes LL-37 chemotactic properties, and cathelicidin resistance is essential for the pathogenesis of hyperinvasive M1T1 GAS.