Jörg Tschmelitsch

TL;DR: Preoperative chemoradiotherapy, as compared with postoperative cheMoradi therapy, improved local control and was associated with reduced toxicity but did not improve overall survival.

TL;DR: This prospective randomized phase‐III‐trial (CAO/ARO/AIO‐94) compares the efficacy of neoadjuvant RCT to standard postoperative RCT, and reports on the design of the study and first results with regard to toxicity of RCT and postoperative morbidity.

TL;DR: The influence of postoperative complications on survival in patients with locally advanced rectal cancer undergoing combined modality treatment is debatable and the impact of surgical complications on oncological outcomes in patients treated within the randomized CAO/ARO/AIO‐94 trial is evaluated.

TL;DR: Female gender is significantly associated with CRT-induced acute toxicity in rectal cancer, and acute toxicity during CRT may be associated with improved long-term outcome.

TL;DR: Real-world follow-up of patients from the ADMIRE-CD trial indicates that clinical remission of complex perianal fistulas can be sustained in the long term irrespective of whether it is achieved through darvadstrocel administration or maintenance treatment regimens and confirms a favorable long-term safety profile of darVad Strocel.