J
Jorja G. Henikoff
Researcher at Fred Hutchinson Cancer Research Center
Publications - 66
Citations - 21496
Jorja G. Henikoff is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 46, co-authored 64 publications receiving 19163 citations. Previous affiliations of Jorja G. Henikoff include Memorial Sloan Kettering Cancer Center & University of Washington.
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Journal ArticleDOI
Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation
TL;DR: CUT&Tag is a tagmentation-based epigenomic profiling method in which antibody tethering of Tn5 to a chromatin epitope of interest profiles specific chromatin features in small samples and single cells and produces chromatin accessibility maps that are indistinguishable from the best ATAC-seq maps.
Journal ArticleDOI
Superior performance in protein homology detection with the Blocks Database servers
TL;DR: The Blocks Database World Wide Web (http://www.blocks.fhcrc.org ) and Email (blocks@blocks.org) servers provide tools for the detection and analysis of protein homology based on alignment blocks representing conserved regions of proteins.
Journal ArticleDOI
Recent enhancements to the Blocks Database servers
TL;DR: The Blocks Database contains multiple alignments of conserved regions in protein families which can be searched by e-mail (blocks@blocks.fhcrc.org) and World Wide Web servers to classify protein and nucleotide sequences.
Journal ArticleDOI
“Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
TL;DR: High-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point Centromere model.
Book ChapterDOI
High-throughput TILLING for Arabidopsis.
Bradley J. Till,Trenton Colbert,Christine A. Codomo,Linda C. Enns,Jessica Johnson,Steven H. Reynolds,Jorja G. Henikoff,Elizabeth A. Greene,Michael N. Steine,Luca Comai,Steven Henikoff +10 more
TL;DR: This chapter describes the basic methodology for high-throughput TILLING, and describes how gene segments are amplified using fluorescently tagged primers, and products are denatured and reannealed to form heteroduplexes between the mutated sequence and its wild-type counterpart.