J
Jorum Kirundi
Researcher at McMaster University
Publications - 5
Citations - 1110
Jorum Kirundi is an academic researcher from McMaster University. The author has contributed to research in topics: Microbiome & Colonisation resistance. The author has an hindex of 4, co-authored 4 publications receiving 953 citations. Previous affiliations of Jorum Kirundi include University of Bern.
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Journal ArticleDOI
Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses
Siegfried Hapfelmeier,Melissa A. E. Lawson,Emma Slack,Jorum Kirundi,Maaike Stoel,Mathias Heikenwalder,Julia Cahenzli,Yuliya Velykoredko,Maria L. Balmer,Kathrin Endt,Markus B. Geuking,Roy Curtiss,Kathy D. McCoy,Andrew J. Macpherson +13 more
TL;DR: A reversible germ-free colonization system in mice that is independent of diet or antibiotic manipulation is reported, and specific IgA induction occurred as a stepwise response to current bacterial exposure, such that the antibody repertoire matched the existing commensal content.
Journal ArticleDOI
Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria
Bärbel Stecher,Samuel Chaffron,Rina Käppeli,Siegfried Hapfelmeier,Susanne Freedrich,Thomas C. Weber,Jorum Kirundi,Mrutyunjay Suar,Kathy D. McCoy,Christian von Mering,Andrew J. Macpherson,Wolf-Dietrich Hardt +11 more
TL;DR: Comparative microbiota analysis of mice with varying degrees of colonization resistance allowed us to identify intestinal ecosystem characteristics associated with susceptibility to S. enterica infection and provided evidence that this principle might be of general validity for invasion of bacteria in preformed gut ecosystems.
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Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels.
Sheida Moghadamrad,Kathy D. McCoy,Markus B. Geuking,Hans Sägesser,Jorum Kirundi,Andrew J. Macpherson,Andrea De Gottardi +6 more
TL;DR: In the complete absence of gut microbial flora PP is normal, but experimental PH is significantly attenuated, and intestinal mucosal lymphatic and blood vessels induced by bacterial colonization may contribute to development of PH.
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Attenuated fibrosis in specific pathogen-free microbiota in experimental cholestasis- and toxin-induced liver injury
Sheida Moghadamrad,Mohsin Hassan,Kathleen McCoy,Jorum Kirundi,Philipp Kellmann,Andrea De Gottardi +5 more
TL;DR: In 2 models of advanced CLD, SPF mice presented significantly attenuated liver injury, fibrosis, and PHT compared to ASF mice, suggesting that a complex intestinal microbiota may play a “hepatoprotective” role.
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Microbiome-liver crosstalk: A multihit therapeutic target for liver disease.
TL;DR: In this article , the authors investigated how the mechanisms of colonization resistance influence the liver in health and disease and the microbial-liver crosstalk potential as therapeutic target areas.