Mathias Heikenwalder

TL;DR: It is shown that oncogene-induced senescence occurs in otherwise normal murine hepatocytes in vivo, and how the cellularsenescence program is involved in tumour immune surveillance by mounting specific immune responses against antigens expressed in pre-malignant senescent cells is illustrated.

TL;DR: It is found that mouse microglia were derived from primitive c-kit+ erythromyeloid precursors that were detected in the yolk sac as early as 8 d post conception and microgliogenesis was not only dependent on the transcription factor Pu.1, but also required Irf8, which was vital for the development of the A2 population, whereas Myb, Id2, Batf3 and Klf4 were not required.

TL;DR: Using a panel of bone marrow chimeric and adoptive transfer experiments, it is found that circulating Ly-6ChiCCR2+ monocytes were preferentially recruited to the lesioned brain and differentiated into microglia.

TL;DR: By transiently colonizing pregnant female mice, it is shown that the maternal microbiota shapes the immune system of the offspring and Pups born to mothers transiently Colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes.

TL;DR: It is described how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and proposed lymphotoxin-β receptor activation as a therapeutic alternative and the development of new therapeutics that, in combination with existing antivirals, may cure hepatitis B.