J
José A. Esté
Researcher at Autonomous University of Barcelona
Publications - 189
Citations - 8989
José A. Esté is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 48, co-authored 189 publications receiving 8583 citations. Previous affiliations of José A. Esté include Rega Institute for Medical Research & Rafael Advanced Defense Systems.
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Journal ArticleDOI
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
G A Donzella,Dominique Schols,Steven Lin,José A. Esté,Kirsten A. Nagashima,Paul J. Maddon,Graham P. Allaway,Thomas P. Sakmar,Geoffrey W. Henson,E. De Clercq,John P. Moore +10 more
TL;DR: The bicyclam AMD3100 blocks HIV-1 entry and membrane fusion via the CXCR4 co-receptor, but not via CCR5, and development of small molecule inhibitors of HIV- 1 entry is feasible.
Journal ArticleDOI
Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
TL;DR: The bicyclams are, to the authors' knowledge, the first low molecular weight anti-HIV agents shown to act as potent and selective CXCR4 antagonists.
Journal ArticleDOI
HIV entry inhibitors.
José A. Esté,Amalio Telenti +1 more
TL;DR: A review of the development of new HIV entry inhibitors, their performance in clinical trials, and their possible role in anti-HIV therapy can be found in this paper, where the authors focus on the entry and post-entry steps of the HIV replication cycle.
Journal ArticleDOI
Current status and challenges of antiretroviral research and therapy.
José A. Esté,Tomas Cihlar +1 more
TL;DR: The principal milestones of antiretroviral research over 25 years of drug discovery and development are highlighted and a comprehensive analysis by leading experts of the efforts being made to meet the challenges of effective control of HIV infection is offered.
Journal ArticleDOI
Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication.
Miguel Angel Martinez,Arantxa Gutiérrez,Mercedes Armand-Ugón,Julià Blanco,Mariona Parera,Jordi Gómez,Bonaventura Clotet,José A. Esté +7 more
TL;DR: The results demonstrate that RNAi may be used to block HIV entry and replication through the blockade of cellular gene expression and Gene silencing by siRNA may become a valid alternative for HIV intervention.