S
Sofie Struyf
Researcher at Rega Institute for Medical Research
Publications - 218
Citations - 14493
Sofie Struyf is an academic researcher from Rega Institute for Medical Research. The author has contributed to research in topics: Chemokine & CXCL2. The author has an hindex of 64, co-authored 206 publications receiving 12750 citations. Previous affiliations of Sofie Struyf include Katholieke Universiteit Leuven & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul,Cecile Loison,Sofie Struyf,Jean-Yves Springael,Vincent Lannoy,Marie-Eve Decobecq,Stéphane Brézillon,Vincent Dupriez,Gilbert Vassart,Jozef Van Damme,Marc Parmentier,Michel Detheux +11 more
TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
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The CC chemokine CCL20 and its receptor CCR6.
TL;DR: The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T- cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis.
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The role of CXC chemokines and their receptors in cancer
TL;DR: The role of CXC chemokines and their receptors in tumorigenesis, including angiogenesis, attraction of leukocytes to tumor sites and induction of tumor cell migration and homing in metastatic sites is discussed.
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Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
TL;DR: The bicyclams are, to the authors' knowledge, the first low molecular weight anti-HIV agents shown to act as potent and selective CXCR4 antagonists.
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Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
Paul Proost,Ingrid De Meester,Dominique Schols,Sofie Struyf,Anne-Marie Lambeir,Anja Wuyts,Ghislain Opdenakker,Erik De Clercq,Simon Scharpé,Jo Van Damme +9 more
TL;DR: Proteolytic processing of RANTES by CD26/dipeptidyl-peptidase IV may constitute an important regulatory mechanism during anti-inflammatory and antiviral responses.