J
José A. Luchsinger
Researcher at Columbia University
Publications - 267
Citations - 21579
José A. Luchsinger is an academic researcher from Columbia University. The author has contributed to research in topics: Dementia & Risk factor. The author has an hindex of 68, co-authored 231 publications receiving 19153 citations. Previous affiliations of José A. Luchsinger include Columbia University Medical Center & University of California, Davis.
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Journal ArticleDOI
Candidate genes for Alzheimer’s disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome
Nicole Schupf,Annie J. Lee,Naeun Park,Lam Ha Dang,Deborah Pang,Alexander Yale,David Kyung Taek Oh,Sharon J. Krinsky-McHale,Edmund C. Jenkins,José A. Luchsinger,Warren B. Zigman,Wayne Silverman,Benjamin Tycko,Sergey Kisselev,Lorraine N. Clark,Joseph H. Lee +15 more
TL;DR: Broadly classified, variants in these genes may influence amyloid precursor protein processing (CALHM1, IDE), vesicular trafficking (SORCS1), and response to oxidative stress (SOD1).
Journal ArticleDOI
White matter hyperintensity volume and impaired mobility among older adults
Joshua Z. Willey,Nikolaos Scarmeas,Frank A. Provenzano,José A. Luchsinger,Richard Mayeux,Adam M. Brickman +5 more
TL;DR: Examination of the association between a decline in gait speed and total and regional WMH volumes in a community-based study of aging found prevention of WMH presents a potential strategy for the prevention of gaitSpeed decline.
Journal ArticleDOI
Subclinical Hearing Loss is Associated With Depressive Symptoms.
Justin S. Golub,Katharine K. Brewster,Adam M. Brickman,Adam Ciarleglio,Ana H. Kim,José A. Luchsinger,Bret R. Rutherford +6 more
TL;DR: The relationship between hearing and clinically significant depressive symptoms is present among older adults with normal hearing and the term subclinical HL is introduced as imperfect hearing that is classically defined as normal (1-25 dB).
BookDOI
Diabetes and the brain
TL;DR: The corner stone of the treatment of type 1 diabetes is exogenous insulin substitution aiming to restore near-normal glycemia in order to prevent or delay long-term complications.
Journal ArticleDOI
Audiometric Age-Related Hearing Loss and Cognition in the Hispanic Community Health Study.
TL;DR: In the largest study of formal, audiometric HL and cognition to date, HL was independently associated with worse performance in a range of neurocognitive measures and should be investigated as a modifiable risk factor for neuroc cognitive decline and dementia.