J
José Bargas
Researcher at National Autonomous University of Mexico
Publications - 115
Citations - 5444
José Bargas is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Dopaminergic & Inhibitory postsynaptic potential. The author has an hindex of 37, co-authored 110 publications receiving 5181 citations. Previous affiliations of José Bargas include Okinawa Institute of Science and Technology.
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Journal ArticleDOI
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons
D. James Surmeier,José Bargas,Hugh C. Hemmings,Hugh C. Hemmings,Angus C. Nairn,Paul Greengard +5 more
TL;DR: The differential regulation of HVA currents by the D1 pathway helps to explain the diversity of effects this pathway has on synaptic integration and plasticity in medium spiny neurons.
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D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade
Salvador Hernández-López,Tatiana Tkatch,Enrique Pérez-Garci,Elvira Galarraga,José Bargas,Heidi E. Hamm,D. James Surmeier +6 more
TL;DR: The studies presented here reveal that D2 receptor stimulation in enkephalin-expressing medium spiny neurons suppresses transmembrane Ca2+ currents through L-type Ca2- channels, resulting in diminished excitability, and provides a foundation for understanding how this pivotal receptor shapes striatal excitability and gene expression.
Journal ArticleDOI
D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance
TL;DR: The results reconcile previous in vitro and in vivostudies by showing that D1 dopamine receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization.
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Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons
TL;DR: Although adult neostriatal projection neurons do not express significant levels of LVA Ca2+ current, they do express a pharmacologically and structurally heterogeneous population of HVA currents.
Journal ArticleDOI
Encoding network states by striatal cell assemblies.
Luis Carrillo-Reid,Fatuel Tecuapetla,Dagoberto Tapia,Arturo Hernández-Cruz,Elvira Galarraga,René Drucker-Colín,José Bargas +6 more
TL;DR: The network dynamics set into action by NMDA in the striatal network may reveal important properties of striatal microcircuits under normal and pathological conditions.