J
Jose L. Pascual
Researcher at University of Pennsylvania
Publications - 128
Citations - 3282
Jose L. Pascual is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Traumatic brain injury. The author has an hindex of 29, co-authored 116 publications receiving 2639 citations. Previous affiliations of Jose L. Pascual include University of Texas Southwestern Medical Center & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Necrotizing fasciitis: current concepts and review of the literature.
TL;DR: An evidence-based review of the icrobiology, pathophysiology, diagnosis, and treatment of the NSTI is provided, based on retrospective and nonblinded study data vailable.
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Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension
Mauro Oddo,Joshua M. Levine,Suzanne Frangos,Emmanuel Carrera,Eileen Maloney-Wilensky,Jose L. Pascual,W. A. Kofke,Stephan A. Mayer,Peter D. LeRoux +8 more
TL;DR: In patients with severe TBI and elevated ICP refractory to previous mannitol treatment, 7.5% hypertonic saline administered as second tier therapy is associated with a significant increase in brain oxygenation, and improved cerebral and systemic haemodynamics.
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Hypertonic Saline Resuscitation of Hemorrhagic Shock Diminishes Neutrophil Rolling and Adherence to Endothelium and Reduces In Vivo Vascular Leakage
Jose L. Pascual,Lorenzo E. Ferri,Andrew J.E. Seely,Giuseppina Campisi,Prosanto Chaudhury,Betty Giannias,David C. Evans,Tarek Razek,René P. Michel,Nicolas V. Christou +9 more
TL;DR: HTS could serve as a novel means of immunomodulation in hemorrhagic shock victims, potentially reducing PMN-mediated tissue injury and reducing vascular permeability in vivo by altering PMN–EC interactions.
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Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance.
TL;DR: This article presents a review and analysis of the evidence that the neutrophil membrane plays a central role in regulating neutrophic delivery, function, and clearance (apoptosis and necrosis), and characterization of neutrophIL membrane expression represents a technology with which to evaluate neutrophils function.
Journal ArticleDOI
Hypertonic saline resuscitation attenuates neutrophil lung sequestration and transmigration by diminishing leukocyte-endothelial interactions in a two-hit model of hemorrhagic shock and infection.
Jose L. Pascual,Kosar Khwaja,Lorenzo E. Ferri,Betty Giannias,David C Evans,Tarek Razek,René P. Michel,Nicolas V. Christou +7 more
TL;DR: Compared with RL, HTS resuscitation attenuates early EC-PMN adhesion and late lung PMN accumulation in hemorrhagic shock followed by inflammation and may attenuate PMN-mediated organ damage.