J
Joshua M. Levine
Researcher at University of Pennsylvania
Publications - 91
Citations - 3730
Joshua M. Levine is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Subarachnoid hemorrhage & Intracranial pressure. The author has an hindex of 30, co-authored 90 publications receiving 3305 citations. Previous affiliations of Joshua M. Levine include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury : A microdialysis study
Mauro Oddo,J. Michael Schmidt,Emmanuel Carrera,Neeraj Badjatia,E. Sander Connolly,Mary Presciutti,Noeleen Ostapkovich,Joshua M. Levine,Peter D. Le Roux,Stephan A. Mayer +9 more
TL;DR: In patients with severe brain injury, tight systemic glucose control is associated with reduced cerebral extracellular glucose availability and increased prevalence of brain energy crisis, which in turn correlates with increased mortality.
Journal ArticleDOI
Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults
Meeri N. Kim,Turgut Durduran,Suzanne Frangos,Brian L. Edlow,Erin M. Buckley,Heather E. Moss,Chao Zhou,Guoqiang Yu,Guoqiang Yu,Regine Choe,Eileen Maloney-Wilensky,Ronald L. Wolf,M. Sean Grady,Joel H. Greenberg,Joshua M. Levine,Arjun G. Yodh,John A. Detre,W. Andrew Kofke +17 more
TL;DR: The potential for DCS to provide continuous, noninvasive bedside monitoring for the purpose of CBF management and individualized care is demonstrated.
Journal ArticleDOI
Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury
Alejandro M Spiotta,Michael F. Stiefel,Vicente H. Gracias,Alicia M. Garuffe,W. Andrew Kofke,Eileen Maloney-Wilensky,Andrea B. Troxel,Joshua M. Levine,Peter D. Le Roux +8 more
TL;DR: It is suggested that PbtO(2)-based therapy, particularly when compromised Pbt O(2) can be corrected, may be associated with reduced patient mortality and improved patient outcome after severe TBI.
Journal ArticleDOI
Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension
Mauro Oddo,Joshua M. Levine,Suzanne Frangos,Emmanuel Carrera,Eileen Maloney-Wilensky,Jose L. Pascual,W. A. Kofke,Stephan A. Mayer,Peter D. LeRoux +8 more
TL;DR: In patients with severe TBI and elevated ICP refractory to previous mannitol treatment, 7.5% hypertonic saline administered as second tier therapy is associated with a significant increase in brain oxygenation, and improved cerebral and systemic haemodynamics.
Journal ArticleDOI
Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure.
Mauro Oddo,Mauro Oddo,Joshua M. Levine,Larami MacKenzie,Suzanne Frangos,François Feihl,Scott E. Kasner,Michael Katsnelson,Bryan Pukenas,Eileen MacMurtrie,Eileen Maloney-Wilensky,W. Andrew Kofke,Peter D. LeRoux +12 more
TL;DR: Brain hypoxia is associated with poor short-term outcome after severe traumatic brain injury independently of elevated ICP, low CPP, and injury severity and may be an important therapeutic target after severetraumatic brain injury.