J
Josep Chillarón
Researcher at University of Barcelona
Publications - 30
Citations - 2333
Josep Chillarón is an academic researcher from University of Barcelona. The author has contributed to research in topics: Amino acid & Cystine. The author has an hindex of 22, co-authored 30 publications receiving 2197 citations.
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Journal ArticleDOI
Cystinuria caused by mutations in rBAT , a gene involved in the transport of cystine
Maria Julia Calonge,Paolo Gasparini,Josep Chillarón,Miguel Chillón,Michele Gallucci,Ferran Rousaud,Leopoldo Zelante,Xavier Testar,Bruno Dallapiccola,Franco Di Silverio,Pedro Barceló,Xavier Estivill,Antonio Zorzano,Virginia Nunes,Manuel Palacín +14 more
TL;DR: RBAT is established as a cystinuria gene, which involves the defective transepithelial transport of cystine and dibasic amino acids in the kidney and intestine and nearly abolished the amino acid transport activity induced by rBAT in Xenopus oocytes.
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Heteromeric amino acid transporters: biochemistry, genetics, and physiology
TL;DR: This review covers the biochemistry, human genetics, and cell physiology of HATs, including the multifunctional character of CD98, the heavy subunit of the cell-surface antigen 4F2 (also named CD98), which is involved in other cell functions that might be related to integrin activation.
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Pathophysiology and treatment of cystinuria
Josep Chillarón,Mariona Font-Llitjós,Joana Fort,Antonio Zorzano,David S. Goldfarb,Virginia Nunes,Manuel Palacín +6 more
TL;DR: This Review examines the molecular and mechanistic effects of some of the mutations that cause cystinuria based on the current understanding of the structural and cellular biology of the amino acid transport system b0,+.
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Obligatory Amino Acid Exchange via Systems bo,+-like and y+L-like A TERTIARY ACTIVE TRANSPORT MECHANISM FOR RENAL REABSORPTION OF CYSTINE AND DIBASIC AMINO ACIDS
Josep Chillarón,Raúl Estévez,Conchi Mora,Carsten A. Wagner,Hartmut Suessbrich,Florian Lang,Josep Lluís Gelpí,Xavier Testar,Andreas E. Busch,Antonio Zorzano,Manuel Palacín +10 more
TL;DR: Evidence is offered that system bo,+-like is an obligatory amino acid exchanger in oocytes and in the “renal proximal tubular” cell line OK that is based on their active tertiary transport mechanism and on the apical and basolateral localization of rBAT and 4F2hc, respectively, in the epithelial cells of the proximaltubule of the nephron.
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The genetics of heteromeric amino acid transporters.
Manuel Palacín,Virginia Nunes,Mariona Font-Llitjós,Maite Jiménez-Vidal,Joana Fort,Emma Gasol,Marta Pineda,Lídia Feliubadaló,Josep Chillarón,Antonio Zorzano +9 more
TL;DR: Heteromeric amino acid transporters (HATs) are composed of a heavy (SLC3 family) and a light subunit and have begun to reveal the basis of renal and intestinal reabsorption of amino acids in mammals.