J
Joseph A. DiGiuseppe
Researcher at Hartford Hospital
Publications - 64
Citations - 5895
Joseph A. DiGiuseppe is an academic researcher from Hartford Hospital. The author has contributed to research in topics: Immunophenotyping & Population. The author has an hindex of 30, co-authored 63 publications receiving 5595 citations. Previous affiliations of Joseph A. DiGiuseppe include Johns Hopkins University School of Medicine & Washington University in St. Louis.
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Journal ArticleDOI
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Tae Wook Chun,Lucy M. Carruth,Diana Finzi,Xuefei Shen,Joseph A. DiGiuseppe,Harry E. Taylor,Monika Hermankova,Karen Chadwick,Joseph B. Margolick,Thomas C. Quinn,Thomas C. Quinn,Yen Hong Kuo,Ron Brookmeyer,Martha A. Zeiger,Patricia Barditch-Crovo,Robert F. Siliciano +15 more
TL;DR: It is shown that during the asymptomatic phase of infection there is an extremely low total body load of latently infected resting CD4+ T cells with replication-competent integrated pro virus (<107 cells).
Journal ArticleDOI
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
Aaron Ciechanover,Joseph A. DiGiuseppe,Beatrice Bercovich,Amir Orian,Joel D. Richter,Alan L. Schwartz,Garrett M. Brodeur +6 more
TL;DR: The relative sensitivity to degradation of various E1A mutants in vivo is also maintained in the cell-free system, suggesting that the ubiquitin pathway may play a role in the cellular degradation of these proteins as well.
Journal ArticleDOI
Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.
Michael J. Borowitz,Fiona E. Craig,Joseph A. DiGiuseppe,Andrea Illingworth,Wendell F. Rosse,D. Robert Sutherland,Carl T. Wittwer,Stephen J. Richards +7 more
TL;DR: Flow cytometry is the method of choice for identifying cells deficient in GPI‐linked proteins and is, therefore, necessary for the diagnosis of PNH, but to date there has not been an attempt to standardize the methodology used to identify these cells.
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Intravascular lymphomatosis: a clinicopathologic study of 10 cases and assessment of response to chemotherapy.
TL;DR: It is suggested that IVL represents a high-grade non-Hodgkin's lymphoma (NHL) with a propensity for systemic dissemination, and that CR and long-term survival may result in patients treated with aggressive combination chemotherapy.
Journal Article
Pharmacological Inhibitors of Mammalian Fatty Acid Synthase Suppress DNA Replication and Induce Apoptosis in Tumor Cell Lines
TL;DR: The data suggest a direct linkage at a regulatory level, between fatty acid synthesis and DNA synthesis in proliferating tumor cells, as part of a larger effort to understand the immediate downstream effect of FAS inhibition that leads to apoptosis.