J
Joseph A. Lasky
Researcher at University Medical Center New Orleans
Publications - 11
Citations - 880
Joseph A. Lasky is an academic researcher from University Medical Center New Orleans. The author has contributed to research in topics: Pulmonary fibrosis & Growth factor. The author has an hindex of 9, co-authored 11 publications receiving 846 citations. Previous affiliations of Joseph A. Lasky include Tulane Medical Center.
Papers
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Journal ArticleDOI
Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis.
Joseph A. Lasky,Luis A. Ortiz,Boihoang Tonthat,Gary W. Hoyle,Miriam Corti,Grace B. Athas,Giuseppe Lungarella,Arnold R. Brody,Mitchell Friedman +8 more
TL;DR: It is demonstrated that CTGF is expressed in lung fibroblasts and may play a role in the pathogenesis of lung fibrosis.
Journal ArticleDOI
Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice.
Luis A. Ortiz,Joseph A. Lasky,Raymond F. Hamilton,Andrij Holian,Gary W. Hoyle,William Banks,Jacques J. Peschon,Arnold R. Brody,Giuseppe Lungarella,Mitchell Friedman +9 more
TL;DR: It appears that the presence of TNF receptors is necessary for the development of BLM-induced lung injury, and signaling through these receptors may contribute to the regulation of the TGF-beta 1 mRNA expression observed in response to bleomycin.
Journal ArticleDOI
Interstitial fibrosis and growth factors.
Joseph A. Lasky,Arnold R. Brody +1 more
TL;DR: The use of modern molecular and transgenic technologies could elucidate those targets that will allow effective therapeutic approaches to IPF and support the growth factor hypothesis.
Journal ArticleDOI
Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor.
Gary W. Hoyle,Jian Li,Jeffrey B. Finkelstein,Todd Eisenberg,Jing-Yao Liu,Joseph A. Lasky,Grace Athas,Gilbert F. Morris,Arnold R. Brody +8 more
TL;DR: Transgenic mice that express the PDGF-B gene from the lung-specific surfactant protein C promoter induced distinct abnormalities in the developing and adult lung and led to a complex phenotype that encompassed aspects of both emphysema and fibrotic lung disease.
Journal ArticleDOI
Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats
TL;DR: In vivo observations suggest a scenario in which a potent lung mesenchymal cell mitogen, PDGF-AA, and its alpha-receptor are upregulated prior to the development of a fibroproliferative lung lesion, and thus may play a central role in the pathogenesis of asbestos-induced lung fibrosis.