Journal ArticleDOI
Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis.
Joseph A. Lasky,Luis A. Ortiz,Boihoang Tonthat,Gary W. Hoyle,Miriam Corti,Grace B. Athas,Giuseppe Lungarella,Arnold R. Brody,Mitchell Friedman +8 more
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TLDR
It is demonstrated that CTGF is expressed in lung fibroblasts and may play a role in the pathogenesis of lung fibrosis.Abstract:
Connective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts and a promoter of connective tissue deposition in the skin. TheCTGF gene promotor contains a trans...read more
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Liver fibrosis – from bench to bedside
TL;DR: Current knowledge about the nature and prognosis of fibrosis in different forms of chronic liver disease with recent advances in elucidating its pathophysiology form the basis for rational treatment of hepatic fibrosis, which are summarized.
Journal ArticleDOI
Hypoxia and the extracellular matrix: drivers of tumour metastasis
TL;DR: A direct link between hypoxia and the composition and the organization of the ECM is established, which suggests a new model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
Journal ArticleDOI
Bone marrow-derived mesenchymal stem cells in repair of the injured lung.
Mauricio Rojas,Jianguo Xu,Charles R. Woods,Ana L. Mora,Willy Spears,Jesse Roman,Kenneth L. Brigham +6 more
TL;DR: It is concluded that bone marrow stem cells are important in the repair of bleomycin-injured lung and that transfer of mesenchymal stem cells protects against the injury.
Journal ArticleDOI
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
Sanja Ivkovic,Byeong S. Yoon,Steven N. Popoff,Fayez F. Safadi,Diana E. Libuda,Robert C. Stephenson,Aaron Daluiski,Karen M. Lyons +7 more
TL;DR: It is demonstrated that CTGF is important for cell proliferation and Matrix remodeling during chondrogenesis, and is a key regulator coupling extracellular matrix remodeling to angiogenesis at the growth plate.
References
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Book
Peptide Growth Factors and Their Receptors
TL;DR: A comprehensive survey of the chemistry and biology of peptide growth factors is presented in this paper, where the peptides described here are of fundamental importance for understanding the behavior of all cells, and they will be of major importance in the practice of clinical medicine in the years to come.
Journal ArticleDOI
Modifications of a specific assay for hydroxyproline in urine
TL;DR: Several modifications of a specific chemical assay for hydroxyproline in urine are presented which make the procedure more rapid without reducing its specificity or accuracy.
Book ChapterDOI
The Transforming Growth Factor-βs
A. B. Roberts,M. B. Sporn +1 more
TL;DR: This chapter summary of current knowledge of the chemistry and complex biology of the growing family of TGF-βs suggests that it has a pivotal control function in many physiological and pathological processes.
Journal ArticleDOI
Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.
TL;DR: Immunoblot analysis of the affinity- purified proteins with anti-PDGF IgG and antibodies specific for the A or B chain peptides of PDGF combined with chemotactic and mitogenic assays revealed that the major PDGF immunorelated molecule secreted by HUVE cells is a monomer of approximately 36-38 kD.