A
Andrij Holian
Researcher at University of Montana
Publications - 194
Citations - 7893
Andrij Holian is an academic researcher from University of Montana. The author has contributed to research in topics: Alveolar macrophage & Inflammation. The author has an hindex of 52, co-authored 189 publications receiving 7262 citations. Previous affiliations of Andrij Holian include University of Pennsylvania & University of Texas Health Science Center at Houston.
Papers
More filters
Journal ArticleDOI
Silica binding and toxicity in alveolar macrophages.
TL;DR: Current research ideas on silica toxicity and binding in the alveolar macrophage are reviewed and discussed.
Journal ArticleDOI
Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity
Raymond F. Hamilton,Nianqiang Wu,Dale W. Porter,Mary C. Buford,Michael G. Wolfarth,Andrij Holian +5 more
TL;DR: This study demonstrates that alteration of anatase TiO2 nanomaterial into a fibre structure of greater than 15 μm creates a highly toxic particle and initiates an inflammatory response by alveolar macrophages, and suggests that any modification of a nanomMaterial, resulting in a wire, fibre, belt or tube, be tested for pathogenic potential.
Journal ArticleDOI
Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium.
Tian Xia,Raymond F. Hamilton,James C. Bonner,Edward D. Crandall,Alison Elder,Farnoosh Fazlollahi,Teri Girtsman,K.J. Kim,Somenath Mitra,Susana Addo Ntim,Galya Orr,Mani Tagmount,Alexia J. Taylor,Donatello Telesca,Ana Tolic,Chris D. Vulpe,Andrea J. Walker,Xiang Wang,Frank A. Witzmann,Nianqiang Wu,Yumei Xie,J. I. Zink,Andre E. Nel,Andrij Holian +23 more
TL;DR: The results provide justification for the inclusion of mechanism-linked bioactivity assays along with traditional cytotoxicity assays for in vitro screening and suggest that conducting studies with multiple relevant cell types to avoid false-negative outcomes is critical for accurate evaluation of ENM bioactivity.
Journal ArticleDOI
Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice.
Luis A. Ortiz,Joseph A. Lasky,Raymond F. Hamilton,Andrij Holian,Gary W. Hoyle,William Banks,Jacques J. Peschon,Arnold R. Brody,Giuseppe Lungarella,Mitchell Friedman +9 more
TL;DR: It appears that the presence of TNF receptors is necessary for the development of BLM-induced lung injury, and signaling through these receptors may contribute to the regulation of the TGF-beta 1 mRNA expression observed in response to bleomycin.
Journal ArticleDOI
Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages
TL;DR: It is suggested that fibrogenic particulates, such as silica, caused apoptosis of alveolar macrophages and that this apoptotic potential of fibrogenics particulates may be a critical factor in initiating an inflammatory response resulting in fibrosis.