J
Joseph A. Loo
Researcher at University of California, Los Angeles
Publications - 434
Citations - 28705
Joseph A. Loo is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mass spectrometry & Electrospray ionization. The author has an hindex of 89, co-authored 413 publications receiving 26162 citations. Previous affiliations of Joseph A. Loo include University of Massachusetts Amherst & Ohio State University.
Papers
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Journal ArticleDOI
Enhancing protein disulfide bond cleavage by UV excitation and electron capture dissociation for top-down mass spectrometry
Piriya Wongkongkathep,Huilin Li,Xing Zhang,Rachel R. Ogorzalek Loo,Ryan R. Julian,Joseph A. Loo +5 more
TL;DR: Ion pre-activation with 266 nm ultraviolet (UV) laser irradiation combined with electron capture dissociation (ECD) is demonstrated to enhance top-down mass spectrometry sequence coverage of disulfide bond containing proteins.
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Sample introduction and separation in capillary electrophoresis, and combination with mass spectrometric detection.
TL;DR: The interfacing of capillary electrophoresis with mass spectrometry is described and demonstrated for a range of conditions, with a quaternary phosphonium salt mixture, and the relative advantages of the two techniques discussed are discussed.
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Mass spectrometric characterization of transferrins and their fragments derived by reduction of disulfide bonds.
TL;DR: Protein acetylation and MS/MS sequencing demonstrate that the fragment originates from the C-terminus of the protein, and that it is a separate polypeptide linked via three disulfide bonds to the main transferrin chain.
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Radical Directed Dissociation for Facile Identification of Iodotyrosine Residues Using Electrospray Ionization Mass Spectrometry
TL;DR: A facile method employing photodissociation and mass spectrometry to localize sites of iodination in whole proteins, which yields results in agreement with traditional approaches but requires significantly less effort and is inherently more sensitive.
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ProForma: A Standard Proteoform Notation.
Richard D. LeDuc,Veit Schwämmle,Michael R. Shortreed,Anthony J. Cesnik,Stefan K. Solntsev,Jared B. Shaw,Maria Jesus Martin,Juan Antonio Vizcaíno,Emanuele Alpi,Paul O. Danis,Neil L. Kelleher,Lloyd M. Smith,Ying Ge,Jeffrey N. Agar,Julia Chamot-Rooke,Joseph A. Loo,Ljiljana Paša-Tolić,Yury O. Tsybin +17 more
TL;DR: Standardizing proteoform sequences will simplify storage, comparison, and reanalysis of proteomic studies, and the Consortium welcomes input and contributions from the research community on the continued design and maintenance of this standard.