J
Joseph A. Loo
Researcher at University of California, Los Angeles
Publications - 434
Citations - 28705
Joseph A. Loo is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mass spectrometry & Electrospray ionization. The author has an hindex of 89, co-authored 413 publications receiving 26162 citations. Previous affiliations of Joseph A. Loo include University of Massachusetts Amherst & Ohio State University.
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Journal ArticleDOI
Structural Characterization of Native Proteins and Protein Complexes by Electron Ionization Dissociation-Mass Spectrometry.
TL;DR: The capabilities of another activation method, 30 eV electron ionization dissociation (EID), for the top-down MS characterization of native protein-ligand and protein-protein complexes and the structural changes due to Cu-binding and a point mutation were revealed by EID-MS.
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Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43
Y. Jiang,Qin Cao,Michael R. Sawaya,Romany Abskharon,Peng Ge,Michael DeTure,Dennis W. Dickson,Janine Fu,Rachel R. Ogorzalek Loo,Joseph A. Loo,David Eisenberg +10 more
TL;DR: In this paper , the authors extracted amyloid fibrils from four patients representing four of the five FTLD-TDP subclasses, and determined their structures by cryo-electron microscopy.
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Use of electrospray ionization mass spectrometry to probe antisense peptide interactions
TL;DR: Electrospray ionization mass spectrometry with a magnetic sector instrument has been used to test for non-covalent interactions between human angiotensin II and eight synthetic octapeptides that are considered complementary peptides or analogues of these antisense peptides.
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Capillary isotachophoresis with UV and tandem mass spectrometric detection for peptides and proteins.
Richard D. Smith,Steven M. Fields,Joseph A. Loo,Charles J. Barinaga,Harold R. Udseth,Charles G. Edmonts +5 more
TL;DR: The application of capillary isotachophoresis (CITP) and combined CITP‐mass spectrometry (MS) for peptides and proteins is demonstrated, showing the potential for rapid sequence determination.
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Glycoprofiling of the Human Salivary Proteome
Melissa Sondej,Patricia A. Denny,Yongming Xie,Prasanna Ramachandran,Yan Si,Jona Takashima,Wenyuan Shi,David T.W. Wong,Joseph A. Loo,Paul C. Denny +9 more
TL;DR: This starting 2-D gel glycosylation reference map shows that the scientifically accepted, individual oligosaccharide variability is not limited to a few large glycoproteins such as MUC5B, but are found on most members of the salivary proteome.