J
Joseph A. Sorg
Researcher at Texas A&M University
Publications - 64
Citations - 3523
Joseph A. Sorg is an academic researcher from Texas A&M University. The author has contributed to research in topics: Spore germination & Clostridium difficile. The author has an hindex of 26, co-authored 54 publications receiving 2868 citations. Previous affiliations of Joseph A. Sorg include University of Chicago & Tufts University.
Papers
More filters
Journal ArticleDOI
Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores
TL;DR: It is found that cholate derivatives and the amino acid glycine act as cogerminants and Deoxycholate, a metabolite of cholate produced by the normal intestinal flora, induced germination of C.difficile spores but prevented the growth of vegetative C. difficile.
Journal ArticleDOI
Clostridium difficile spore biology: sporulation, germination, and spore structural proteins
TL;DR: The regulation of the sporulation and germination pathways and the morphogenesis of the spore coat and exosporium will be discussed.
Journal ArticleDOI
Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid
TL;DR: By applying Michaelis-Menten kinetic analysis to C. difficile spore germination, chenodeoxycholate is a competitive inhibitor of taurocholate-mediated germination and appears to interact with the spores with greater apparent affinity than does tau rocholate.
Journal ArticleDOI
Bile acid recognition by the Clostridium difficile germinant receptor, CspC, is important for establishing infection.
TL;DR: It is shown that bile acid-mediated germination is important for establishing C. difficile disease in the hamster model of infection and the first description of a C.difficile spore germinant receptor is provided, which may represent an attractive target for novel therapeutics.
Journal ArticleDOI
Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination
TL;DR: It is shown that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.