J
Joseph Bonaventura
Researcher at Duke University
Publications - 210
Citations - 10497
Joseph Bonaventura is an academic researcher from Duke University. The author has contributed to research in topics: Hemoglobin & Oxygen binding. The author has an hindex of 48, co-authored 210 publications receiving 10225 citations. Previous affiliations of Joseph Bonaventura include University of Richmond & Montana State University.
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S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
TL;DR: In this article, the role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications, highlighting newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure.
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Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient
Jonathan S. Stamler,Li Jia,Jerry P. Eu,Timothy J. McMahon,Ivan T. Demchenko,Joseph Bonaventura,Kim Gernert,Claude A. Piantadosi +7 more
TL;DR: By sensing the physiological oxygen gradient in tissues, hemoglobin exploits conformation-associated changes in the position of cysteinebeta93 SNO to bring local blood flow into line with oxygen requirements.
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Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences
TL;DR: The X‐ray structure of an oxygenated hemocyanin molecule, subunit II of Limulus polyphemus hemocynin, was determined at 2.4 Å resolution and refined to a crystallographic R‐factor of 17.1%.
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Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation.
Bart Hazes,Karen A. Magnus,Celia Bonaventura,Joseph Bonaventura,Zbigniev Dauter,Kor H. Kalk,W.G.J. Hol +6 more
TL;DR: The rigid body rotation of the first domain suggests a structural mechanism for the allosteric regulation by chloride ions and probably causes the cooperative transition of the hexamer between low and high oxygen affinity states.
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Barnacle in vitro assays for biologically active substances: Toxicity and Settlement inhibition assays using mass cultured Balanus amphitrite amphitrite darwin
TL;DR: The laboratory assays provided provide quantitative estimates of toxicity and settlement inhibition of barnacles, providing an excellent system for the use of barnacle to study the interaction of the test compounds and surfaces.