J
Jerry P. Eu
Researcher at Duke University
Publications - 26
Citations - 4524
Jerry P. Eu is an academic researcher from Duke University. The author has contributed to research in topics: Ryanodine receptor & RYR1. The author has an hindex of 21, co-authored 26 publications receiving 4381 citations. Previous affiliations of Jerry P. Eu include Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient
Jonathan S. Stamler,Li Jia,Jerry P. Eu,Timothy J. McMahon,Ivan T. Demchenko,Joseph Bonaventura,Kim Gernert,Claude A. Piantadosi +7 more
TL;DR: By sensing the physiological oxygen gradient in tissues, hemoglobin exploits conformation-associated changes in the position of cysteinebeta93 SNO to bring local blood flow into line with oxygen requirements.
Journal ArticleDOI
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
TL;DR: Results reveal that ion channels can differentiate nitrosative from oxidative signals and indicate that the cardiac calcium release channel (ryanodine receptor) in canines is regulated by posttranslational chemical modification(s) of sulfurs.
Journal ArticleDOI
The skeletal muscle calcium release channel: Coupled O2 sensor and NO signaling functions
TL;DR: The demonstration that channel cysteine residues subserve coupled O2 sensor and NO regulatory functions and that these operate through the prototypic allosteric effector calmodulin may have general implications for the regulation of redox-related systems.
Journal ArticleDOI
STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle
Jonathan A. Stiber,April F. Hawkins,Zhu-Shan Zhang,Sunny M. C. Wang,Jarrett Burch,Victoria Graham,Cary C Ward,Malini Seth,Elizabeth A. Finch,Nadia N. Malouf,R. Sanders Williams,Jerry P. Eu,Paul B. Rosenberg +12 more
TL;DR: It is shown that stromal interaction molecule 1 is expressed in both myotubes and adult skeletal muscle, and it is suggested that STIM1 has a universal role as an ER/SR calcium sensor in both excitable and non-excitable cells.
Journal ArticleDOI
Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO
TL;DR: The results reveal that different cysteines within the channel have been adapted to serve in nitrosative and oxidative responses, and that S-nitrosylation of the cysteine-containing CaM-binding domain underlies the mechanism of CaM -dependent regulation of RyR1 by NO.