J
Joseph C. Santoro
Researcher at University of Massachusetts Medical School
Publications - 15
Citations - 2926
Joseph C. Santoro is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: DNA vaccination & Gene gun. The author has an hindex of 14, co-authored 14 publications receiving 2899 citations. Previous affiliations of Joseph C. Santoro include University of Massachusetts Amherst.
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Journal ArticleDOI
DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations
Ellen F. Fynan,Robert G. Webster,Deborah H. Fuller,Joel R. Haynes,Joseph C. Santoro,Harriet L. Robinson +5 more
TL;DR: By far the most efficient DNA immunizations were achieved by using a gene gun to deliver DNA-coated gold beads to the epidermis, and 95% protection was achieved by two immunizations with beads loaded with as little as 0.4 micrograms of DNA.
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Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates.
Michael J. McCluskie,Michael J. McCluskie,Cynthia L. Brazolot Millan,Robert A. Gramzinski,Harriet L. Robinson,Joseph C. Santoro,James T. Fuller,Georg Widera,Joel R. Haynes,Robert H. Purcell,Heather L. Davis +10 more
TL;DR: Route of administration of plasmid DNA vaccines influences the strength and nature of immune responses in mice and non-human primates, however, the results in mice were not always predictive of those in monkeys and this is likely true for humans as well.
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Simian immunodeficiency virus DNA vaccine trial in macaques.
Shan Lu,James Arthos,David C. Montefiori,Yasuhiro Yasutomi,Kelledy Manson,Farah Mustafa,Eric A. Johnson,Joseph C. Santoro,J. Wissink,James I. Mullins,Joel R. Haynes,Norman L. Letvin,Michael S. Wyand,Harriet L. Robinson +13 more
TL;DR: The DNA vaccine raised both neutralizing antibody and cytotoxic T-lymphocyte responses and provided some attenuation of the acute phase of infection, but it did not prevent the loss of CD4+ cells.
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Protection of ferrets against influenza challenge with a DNA vaccine to the haemagglutinin.
TL;DR: Immunization of ferrets with a plasmid DNA expressing influenza virus haemagglutinin (pCMV/H1 DNA) provided complete protection from challenge with the homologous A/PR/8/34 (H1N1) influenza virus.
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Use of DNAs Expressing HIV-1 Env and Noninfectious HIV-1 Particles to Raise Antibody Responses in Mice
TL;DR: Two DNA constructs encoding portions of the human immunodeficiency virus type-1 (HIV-1) genome have been used to raise antibody responses in BABL/c mice and both DNA vaccine groups exhibited similar cytotoxic activity.