Joseph E. Tietge

TL;DR: A framework designed for this purpose, the adverse outcome pathway (AOP), is discussed, a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment.

TL;DR: Comparisons of LCegg50s indicate that the tested species were approximately 8 to 38 times less sensitive to TCDD than lake trout, the most sensitive species evaluated to date.

TL;DR: There was a general consensus that all known chemicals which interfere with thyroid hormone function and homeostasis act by either inhibiting synthesis, altering serum transport proteins, or by increasing catabolism of thyroid hormones.

TL;DR: It is suggested that UV light should be further considered as a plausible factor contributing to amphibian malformations in field settings as well as the relationship of the UV light dose used in the laboratory to that actually experienced by amphibians in the field is uncertain.

TL;DR: Vinclozolin, M1 and M2 failed to compete for high-affinity, low-capacity testosterone binding sites in fathead minnow brain and ovary cytosolic fractions, suggesting that these chemicals might not act as antiandrogenic properties in the fat head minnow.