M
Michael W. Hornung
Researcher at United States Environmental Protection Agency
Publications - 38
Citations - 4246
Michael W. Hornung is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Thyroid & Deiodinase. The author has an hindex of 22, co-authored 35 publications receiving 3660 citations. Previous affiliations of Michael W. Hornung include University of Wisconsin-Madison & Research Triangle Park.
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Journal ArticleDOI
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
Gerald T. Ankley,Richard S. Bennett,Russell J. Erickson,Dale J. Hoff,Michael W. Hornung,Rodney D. Johnson,David R. Mount,John W. Nichols,Christine L. Russom,Patricia K. Schmieder,Jose A. Serrrano,Joseph E. Tietge,Daniel L. Villeneuve +12 more
TL;DR: A framework designed for this purpose, the adverse outcome pathway (AOP), is discussed, a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment.
Journal ArticleDOI
Effects of the androgenic growth promoter 17‐β‐trenbolone on fecundity and reproductive endocrinology of the fathead minnow
Gerald T. Ankley,Kathleen M. Jensen,Elizabeth A. Makynen,Michael D. Kahl,Joseph J. Korte,Michael W. Hornung,Tala R. Henry,Jeffrey S. Denny,Richard L. Leino,Vickie S. Wilson,Mary C. Cardon,Phillip C. Hartig,L. Earl Gray +12 more
TL;DR: The studies indicate that 17‐β‐trenbolone is a potent androgen and reproductive toxicant in fish and further studies are warranted to assess potential ecological risk.
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Early life stage toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish (Danio rerio).
TL;DR: Zebrafish responsiveness to TCDD early life stage toxicity coupled with the considerable information on developmental biology and genetics of zebrafish provides a foundation for future investigations into the mechanism of T CDD developmental toxicity.
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Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas).
Gerald T. Ankley,Michael D. Kahl,Kathleen M. Jensen,Michael W. Hornung,Joseph J. Korte,Elizabeth A. Makynen,Richard L. Leino +6 more
TL;DR: Results of this study indicate that the proposed fathead minnow assay should effectively identify test chemicals as potential aromatase inhibitors, both in the context of their reproductive toxicity and the specific mechanism of action.
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2,3,7,8-Tetrachlorodibenzo-p-dioxin alters cardiovascular and craniofacial development and function in sac fry of rainbow trout (Oncorhynchus mykiss).
TL;DR: A primary role for arrested heart development and reduced perfusion of tissues with blood in the early-life stage toxicity of TCDD in trout is suggested.