L
Lynette M. Smith
Researcher at University of Nebraska Medical Center
Publications - 309
Citations - 16241
Lynette M. Smith is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Cancer & Diffuse large B-cell lymphoma. The author has an hindex of 57, co-authored 288 publications receiving 14095 citations. Previous affiliations of Lynette M. Smith include Children's Oncology Group & Creighton University.
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Journal ArticleDOI
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
Christine P. Hans,Dennis D. Weisenburger,Timothy C. Greiner,Randy D. Gascoyne,Jan Delabie,German Ott,H. Konrad Muller-Hermelink,Elias Campo,Rita M. Braziel,Elaine S. Jaffe,Zenggang Pan,Pedro Farinha,Lynette M. Smith,Brunangelo Falini,Alison H. Banham,Andreas Rosenwald,Louis M. Staudt,Joseph M. Connors,James O. Armitage,Wing C. Chan +19 more
TL;DR: In summary, immunostains can be used to determine the GCB and non-GCB subtypes of DLBCL and predict survival similar to the cDNA microarray.
Journal ArticleDOI
A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy
William W.L. Choi,Dennis D. Weisenburger,Timothy C. Greiner,Miguel A. Piris,Alison H. Banham,Jan Delabie,Rita M. Braziel,Huimin Geng,Javeed Iqbal,Georg Lenz,Julie M. Vose,Christine P. Hans,Kai Fu,Lynette M. Smith,Min Li,Zhongfeng Liu,Randy D. Gascoyne,Andreas Rosenwald,German Ott,German Ott,Lisa M. Rimsza,Elias Campo,Elaine S. Jaffe,David L. Jaye,Louis M. Staudt,Wing C. Chan +25 more
TL;DR: A new algorithm using GCET1, CD10, BCL6, MUM1, and FOXP1 was derived that closely approximated the GEP classification with 93% concordance and will facilitate risk stratification of DLBCL patients and futureDLBCL research using archival materials.
Journal ArticleDOI
Immunohistochemical Methods for Predicting Cell of Origin and Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab
Paul N. Meyer,Kai Fu,Timothy C. Greiner,Lynette M. Smith,Jan Delabie,Randy D. Gascoyne,German Ott,Andreas Rosenwald,Rita M. Braziel,Elias Campo,Julie M. Vose,Georg Lenz,Louis M. Staudt,Wing C. Chan,Dennis D. Weisenburger +14 more
TL;DR: The Tally algorithm showed the best concordance with the microarray data while maintaining prognostic significance and ease of use.
Journal ArticleDOI
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Javeed Iqbal,George E. Wright,Chao Wang,Andreas Rosenwald,Randy D. Gascoyne,Dennis D. Weisenburger,Timothy C. Greiner,Lynette M. Smith,Shuangping Guo,Ryan A. Wilcox,Bin Tean Teh,Soon Thye Lim,Soon Yong Tan,Lisa M. Rimsza,Elaine S. Jaffe,Elias Campo,Antonio Martinez,Jan Delabie,Rita M. Braziel,James R. Cook,Raymond R. Tubbs,German Ott,Eva Geissinger,Philippe Gaulard,Pier Paolo Piccaluga,Stefano Pileri,Wing Yan Au,Shigeo Nakamura,Masao Seto,Françoise Berger,Laurence de Leval,Joseph M. Connors,James O. Armitage,Julie M. Vose,Wing C. Chan,Louis M. Staudt +35 more
TL;DR: Gene-expression profiles, immunohistochemistry, and IDH2 mutation analysis in reclassified cases supported the validity of the reclassification of PTCL-NOS cases, and high expression of several signatures associated with the tumor microenvironment was significantly associated with outcome.
Journal ArticleDOI
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Javeed Iqbal,Dennis D. Weisenburger,Timothy C. Greiner,Julie M. Vose,Timothy W. McKeithan,Can Küçük,Huimin Geng,Karen E Deffenbacher,Lynette M. Smith,Karen Dybkær,Shigeo Nakamura,Masao Seto,Jan Delabie,Françoise Berger,Florence Loong,Wing Yan Au,Young Hyeh Ko,Ivy Sng,James O. Armitage,Wing C. Chan +19 more
TL;DR: A molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL-not otherwise specified cases was identified and may lead to better therapies and outcome in the future.