Joseph Geradts

TL;DR: Basal-like breast tumors occurred at a higher prevalence among premenopausal African American patients compared with postmenopausal American and non-African American patients in this population-based study, and their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer-specific survival were examined.

TL;DR: In the Carolina Breast Cancer Study, a population-based, case-control study of African-American and white women, the authors found that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity as mentioned in this paper.

TL;DR: The Rb/p16 pathway was abrogated in 49 of the 50 carcinomas studied, all through inactivation of the p16 gene, demonstrating the central role of the Rb / p16 pathway in the development of pancreatic carcinoma.

TL;DR: It is confirmed in a large sample that methylation is a frequent event in NSCLC, can also occur in smoking-damaged nonmalignant lung tissues, and may be the most common mechanism to inactivate cancer-related genes inNSCLC.

TL;DR: It is shown that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metastasis in mouse models of breast cancer.