J
John D. Minna
Researcher at University of Texas Southwestern Medical Center
Publications - 999
Citations - 114533
John D. Minna is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 169, co-authored 951 publications receiving 106363 citations. Previous affiliations of John D. Minna include University of Texas at Dallas & United States Department of Health and Human Services.
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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
Bernard J. Poiesz,Francis W. Ruscetti,Adi F. Gazdar,Paul A. Bunn,John D. Minna,Robert C. Gallo +5 more
TL;DR: The number of these particle-associated proteins is consistent with the expected proteins of a retrovirus, but the sizes of some are distinct from those of most known retroviruses of the primate subgroups.
Journal Article
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.
TL;DR: The clonogenic assay was more sensitive when continuous drug exposures were utilized, although this was primarily related to the increased drug exposure time, and therefore it offers a valid, simple method of assessing chemosensitivity in established cell lines.
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Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Hisayuki Shigematsu,Hisayuki Shigematsu,Li Lin,Takao Takahashi,Masaharu Nomura,Makoto Suzuki,Ignacio I. Wistuba,Kwun M. Fong,Huei Lee,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,Ziding Feng,Jack A. Roth,Joachim Herz,John D. Minna,Adi F. Gazdar +16 more
TL;DR: EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers, and can lead to lung cancer pathogenesis.
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Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer.
Frank Cuttitta,Desmond N. Carney,James L. Mulshine,Terry W. Moody,Joseph Fedorko,Adam Fischler,John D. Minna +6 more
TL;DR: It is demonstrated that a monoclonal antibody to bombesin binds to the C-terminal region of BLPs, blocks the binding of the hormone to cellular receptors and inhibits the clonal growth of SCLC in vitro and the growth ofSCLC xenografts in vivo.
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Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
Mark G. Kris,Bruce E. Johnson,Lynne D. Berry,David J. Kwiatkowski,A. John Iafrate,Ignacio I. Wistuba,Marileila Varella-Garcia,Wilbur A. Franklin,Samuel J. Aronson,Pei Fang Su,Yu Shyr,D. Ross Camidge,Lecia V. Sequist,Bonnie S. Glisson,Fadlo R. Khuri,Edward B. Garon,William Pao,Charles M. Rudin,Joan H. Schiller,Eric B. Haura,Mark A. Socinski,Keisuke Shirai,Heidi Chen,Giuseppe Giaccone,Giuseppe Giaccone,Marc Ladanyi,Kelly Kugler,John D. Minna,Paul A. Bunn +28 more
TL;DR: The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials.