J
Joseph Jargstorf
Researcher at Princess Margaret Cancer Centre
Publications - 2
Citations - 98
Joseph Jargstorf is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Hematopoietic stem cell & Stem cell. The author has an hindex of 2, co-authored 2 publications receiving 43 citations.
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Journal ArticleDOI
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal.
Stephanie Z. Xie,Laura García-Prat,Veronique Voisin,Robin Ferrari,Olga I. Gan,Elvin Wagenblast,Kerstin B. Kaufmann,Andy G.X. Zeng,Andy G.X. Zeng,Shin-ichiro Takayanagi,Ishita Patel,Esther K. Lee,Joseph Jargstorf,Gareth Holmes,Guy Romm,Kristele Pan,Michelle Shoong,Aditi Vedi,Chiara Luberto,Mark D. Minden,Gary D. Bader,Elisa Laurenti,John E. Dick,John E. Dick +23 more
TL;DR: This work identifies a linkage between sphingolipid metabolism, proteostatic quality control systems, and HSC self-renewal and provides therapeutic targets for improving HSC-based cellular therapeutics.
Journal ArticleDOI
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Stephanie Z. Xie,Kerstin B. Kaufmann,Weijia Wang,Michelle Chan-Seng-Yue,Michelle Chan-Seng-Yue,Olga I. Gan,Elisa Laurenti,Elisa Laurenti,Laura García-Prat,Shin-ichiro Takayanagi,Stanley W.K. Ng,Changjiang Xu,Andy G.X. Zeng,Andy G.X. Zeng,Liqing Jin,Jessica McLeod,Elvin Wagenblast,Amanda Mitchell,James A. Kennedy,James A. Kennedy,James A. Kennedy,Qiang Liu,Héléna Boutzen,Melissa Kleinau,Joseph Jargstorf,Gareth Holmes,Yang Zhang,Veronique Voisin,Gary D. Bader,Jean C.Y. Wang,Jean C.Y. Wang,Jean C.Y. Wang,Yusuf A. Hannun,Chiara Luberto,Timm Schroeder,Mark D. Minden,John E. Dick,John E. Dick +37 more
TL;DR: It is shown that S1PR3, a receptor for the bioactive lipid sphingosine-1-phosphate, is a central regulator which drives myeloid differentiation and activates inflammatory programs in both HSC and LSC.