K
Kerstin B. Kaufmann
Researcher at Princess Margaret Cancer Centre
Publications - 30
Citations - 2143
Kerstin B. Kaufmann is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Stem cell & Hematopoietic stem cell. The author has an hindex of 16, co-authored 30 publications receiving 1636 citations. Previous affiliations of Kerstin B. Kaufmann include University of Toronto & Goethe University Frankfurt.
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Journal ArticleDOI
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
Faiyaz Notta,Faiyaz Notta,Sasan Zandi,Sasan Zandi,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Olga I. Gan,Gavin W. Wilson,Gavin W. Wilson,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Jessica McLeod,Elisa Laurenti,Cyrille F. Dunant,John Douglas Mcpherson,John Douglas Mcpherson,Lincoln Stein,Lincoln Stein,Yigal Dror,John E. Dick,John E. Dick +22 more
TL;DR: Using a cell-sorting scheme based on markers linked to Er and Mk lineage specification, it is found that previously described populations of multipotent progenitors (MPPs), CMPs, and megakaryocyte-erythroid progenitor (MEPs) were heterogeneous and could be further purified.
Journal ArticleDOI
Gene therapy on the move
TL;DR: This review focuses on the application of gene therapy for the correction of inherited diseases, the limitations and drawbacks encountered in some of the early clinical trials and the revival of gene Therapy as a powerful treatment option for the Correction of monogenic disorders.
Journal ArticleDOI
Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment.
Aya Ludin,Shiri Gur-Cohen,Karin Golan,Kerstin B. Kaufmann,Tomer Itkin,Chiara Medaglia,Xin-Jiang Lu,Guy Ledergor,Orit Kollet,Tsvee Lapidot +9 more
TL;DR: Deciphering the signaling pathway of ROS in HSC will provide a better understanding of ROS roles in switching HSC from quiescence to activation and vice versa, and will also shed light on the possible roles in leukemia initiation and development.
Journal ArticleDOI
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
Jinghui Zhang,Kelly McCastlain,Hiroki Yoshihara,Beisi Xu,Yunchao Chang,Michelle L. Churchman,Gang Wu,Yongjin Li,Lei Wei,Ilaria Iacobucci,Yu Liu,Chunxu Qu,Ji Wen,Michael N. Edmonson,Debbie Payne-Turner,Kerstin B. Kaufmann,Shin-ichiro Takayanagi,Shin-ichiro Takayanagi,Erno Wienholds,Esmé Waanders,Esmé Waanders,Panagiotis Ntziachristos,Sofia Bakogianni,Jingjing Wang,Iannis Aifantis,Iannis Aifantis,Kathryn G. Roberts,Jing Ma,Guangchun Song,John Easton,Heather L. Mulder,Xiang Chen,Scott Newman,Xiaotu Ma,Michael Rusch,Pankaj Gupta,Kristy Boggs,Bhavin Vadodaria,James Dalton,Yanling Liu,Marcus L Valentine,Li Ding,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,Kerri Ochoa,Meenakshi Devidas,Deqing Pei,Cheng Cheng,Jun J. Yang,William E. Evans,Mary V. Relling,Ching-Hon Pui,Sima Jeha,Richard C. Harvey,I-Ming L. Chen,Cheryl L. Willman,Guido Marcucci,Clara D. Bloomfield,Jessica Kohlschmidt,Krzysztof Mrózek,Elisabeth Paietta,Martin S. Tallman,Wendy Stock,Matthew C. Foster,Janis Racevskis,Jacob M. Rowe,Selina M. Luger,Steven M. Kornblau,Sheila A. Shurtleff,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,John E. Dick,Stephen P. Hunger,Mignon L. Loh,James R. Downing,Charles G. Mullighan +78 more
TL;DR: A unique paradigm of transcription factor deregulation in leukemia is illustrated in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function.
Journal ArticleDOI
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Eric R. Lechman,Eric R. Lechman,Bernhard Gentner,Stanley W.K. Ng,Erwin M. Schoof,Erwin M. Schoof,Peter van Galen,Peter van Galen,James A. Kennedy,James A. Kennedy,Silvia Nucera,Fabio Ciceri,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Aaron Trotman-Grant,Aaron Trotman-Grant,Gabriela Krivdova,Gabriela Krivdova,Janneke Elzinga,Janneke Elzinga,Amanda Mitchell,Amanda Mitchell,Björn Nilsson,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Rene Marke,Ruth Isserlin,Veronique Voisin,Gary D. Bader,Peter W. Zandstra,Todd R. Golub,Benjamin L. Ebert,Jun Lu,Mark D. Minden,Mark D. Minden,Jean C.Y. Wang,Jean C.Y. Wang,Luigi Naldini,John E. Dick,John E. Dick +44 more
TL;DR: Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.