L
Laura García-Prat
Researcher at Princess Margaret Cancer Centre
Publications - 33
Citations - 2910
Laura García-Prat is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Stem cell & Skeletal muscle. The author has an hindex of 15, co-authored 30 publications receiving 1970 citations. Previous affiliations of Laura García-Prat include Centro Nacional de Investigaciones Cardiovasculares & University of Toronto.
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Journal ArticleDOI
Autophagy maintains stemness by preventing senescence
Laura García-Prat,Marta Martinez-Vicente,Eusebio Perdiguero,Laura Ortet,Javier Rodríguez-Ubreva,Elena Rebollo,Ruiz-Bonilla,Susana Gutarra,Esteban Ballestar,Antonio L. Serrano,Marco Sandri,Pura Muñoz-Cánoves +11 more
TL;DR: It is reported that basal autophagy is essential to maintain the stem-cell quiescent state in mice and revealed to be a decisive stem- cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia.
Journal ArticleDOI
Geriatric muscle stem cells switch reversible quiescence into senescence
Pedro Sousa-Victor,Pedro Sousa-Victor,Susana Gutarra,Laura García-Prat,Javier Rodríguez-Ubreva,Laura Ortet,Vanessa Ruiz-Bonilla,Mercè Jardí,Esteban Ballestar,Susana González,Antonio L. Serrano,Eusebio Perdiguero,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves +13 more
TL;DR: It is reported that geriatric satellite cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Journal ArticleDOI
Muscle stem cell aging: regulation and rejuvenation
Pedro Sousa-Victor,Pedro Sousa-Victor,Laura García-Prat,Antonio L. Serrano,Eusebio Perdiguero,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves +6 more
TL;DR: This work focuses particularly on the emergent biology of rejuvenation of old satellite cells, including cells of geriatric age, by restoring traits of youthfulness, with the final goal of improving human health during aging.
Journal ArticleDOI
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells.
TL;DR: The current literature on the coordinated relationship between cell extrinsic and intrinsic factors that regulate the function of satellite cells, and ultimately determine tissue homeostasis and repair during aging, is reviewed to encourage the search for new anti‐aging strategies.
Journal ArticleDOI
Proteostatic and Metabolic Control of Stemness
Laura García-Prat,Laura García-Prat,Pedro Sousa-Victor,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves +4 more
TL;DR: New insights are discussed into how metabolism, mitochondrial dynamics, and protein homeostasis control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells.