Joseph L. Roberts

TL;DR: Observations indicate that the functions of γc are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.

TL;DR: Transplantation of marrow from a related donor is a life-saving and life-sustaining treatment for patients with any type of severe combined immunodeficiency, even when there is no HLA-identical donor.

TL;DR: Microarray data suggest a novel role for apoptosis in OIT, which induces clinical desensitization to peanut, with significant longer-term humoral and cellular changes.

TL;DR: Different SCID genotypes are associated with distinctive lymphocyte characteristics and the presence of NK function in ADA-deficient, autosomal recessive, and unknown type SCIDs, and lowNK function in a majority of gamma c and Jak3 SCIDs indicates that some molecular lesions affect T, B, and NK cells, others primarily T cells (ADA deficiency), and others just T and B cells.

TL;DR: The normal actions of the gammac cytokines, the pathogenesis and treatment protocols for SCID, and finally, the production of a new, selective Jak3 inhibitor capable of preventing transplant rejection in two animal models are discussed.