M
Masayuki Noguchi
Researcher at National Institutes of Health
Publications - 18
Citations - 5540
Masayuki Noguchi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: X-linked severe combined immunodeficiency & Severe combined immunodeficiency. The author has an hindex of 13, co-authored 18 publications receiving 5390 citations.
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Journal ArticleDOI
Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans
Masayuki Noguchi,H Yi,Howard M. Rosenblatt,A H Filipovich,Stephen Adelstein,William S. Modi,O W McBride,Warren J. Leonard +7 more
TL;DR: In this article, the IL-2R gamma gene and the locus for X-linked severe combined immunodeficiency (XSCID) appear to be at the same position.
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Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
Masayuki Noguchi,Yoshiaki Nakamura,Sarah M. Russell,Steven F. Ziegler,Monica Tsang,Xiqing Cao,Warren J. Leonard +6 more
TL;DR: Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma, which was shown to be physically associated with the IL-7 receptor by using chemical cross-linking.
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Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.
Xiqing Cao,Elizabeth W. Shores,Jane Hu-Li,Miriam R. Anver,Brian L. Kelsail,Sarah M. Russell,John Drago,Masayuki Noguchi,Alexander Grinberg,Eda T. Bloom,William E. Paul,Stephen I. Katz,Paul E. Love,Warren J. Leonard +13 more
TL;DR: Differences in humans and mice lacking gamma c expression indicate species-specific differences in the roles of gamma c-dependent cytokines or in the existence of redundant pathways.
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Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
Sarah M. Russell,Nahid Tayebi,Hiroshi Nakajima,M. C. Riedy,Joseph L. Roberts,M. Javad Aman,Thi-Sau Migone,Masayuki Noguchi,M. Louise Markert,Rebecca H. Buckley,John J. O'Shea,Warren J. Leonard +11 more
TL;DR: Observations indicate that the functions of γc are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.
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Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3 : implications for XSCID and XCID
Sarah M. Russell,James A. Johnston,Masayuki Noguchi,Masaru Kawamura,Chris M. Bacon,Michael Friedmann,Maria Berg,Daniel W. McVicar,Bruce A. Witthuhn,Olli Silvennoinen,Armond S. Goldman,Frank C. Schmalstieg,James N. Ihle,John J. O'Shea,Warren J. Leonard +14 more
TL;DR: Gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCIDs-like phenotype.