J
Josepha Tiobech
Publications - 15
Citations - 385
Josepha Tiobech is an academic researcher. The author has contributed to research in topics: Population & Schizophrenia. The author has an hindex of 9, co-authored 15 publications receiving 379 citations.
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Journal ArticleDOI
Evidence for a chromosome 2p13-14 schizophrenia susceptibility locus in families from Palau, Micronesia
Hilary Coon,Marina Myles-Worsley,Josepha Tiobech,Mark Hoff,J. Rosenthal,P. Bennett,Frederick W. Reimherr,Paul H. Wender,Paul W. Dale,Anthony Polloi,William Byerley +10 more
TL;DR: The linkage and haplotype sharing results provide suggestive evidence for a 2p locus predisposing to schizophrenia in a subset of families in the Palauan population.
Journal ArticleDOI
Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.
Nicola J. Camp,Susan L. Neuhausen,Josepha Tiobech,Anthony Polloi,Hilary Coon,Marina Myles-Worsley +5 more
TL;DR: These findings provide significant evidence for susceptibility loci on chromosomes 2p13-14 and 13q12-22 and support both a model of genetic heterogeneity and the utility of a broader set of diagnostic classifications in the population from Palau.
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Genetic epidemiological study of schizophrenia in Palau, Micronesia: Prevalence and familiality
Marina Myles-Worsley,Hilary Coon,Josepha Tiobech,Jay Collier,Paul W. Dale,Paul H. Wender,Frederick W. Reimherr,Anthony Polloi,William Byerley +8 more
TL;DR: These Palauan families represent a valuable resource for studying the genetic etiology of schizophrenia because there may be fewer susceptibility genes for schizophrenia in this genetic isolate than in the heterogeneous populations that are common throughout the world today.
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Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family.
Marina Myles-Worsley,Josepha Tiobech,Sharon R. Browning,Jeremy Korn,Sarah Goodman,Karen L. Gentile,Nadine M. Melhem,William Byerley,Stephen V. Faraone,Frank A. Middleton +9 more
TL;DR: Discovery of this functionally relevant SLC1A1 mutation and its co‐segregation with psychosis in an extended multigenerational pedigree provides further support for the important role played by glutamatergic transmission in the pathophysiology of psychotic disorders.
Journal ArticleDOI
Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees.
Nadine M. Melhem,Frank A. Middleton,Kathryn McFadden,Lambertus Klei,Stephen V. Faraone,Sophia Vinogradov,Josepha Tiobech,Victor Yano,Stevenson Kuartei,Kathryn Roeder,William Byerley,Bernie Devlin,Marina Myles-Worsley +12 more
TL;DR: This study reveals CNVs that confer risk to schizophrenia and related psychotic disorders in Palau, most of which have been previously observed in samples of European ancestry.